Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

基于手机的无线搜索技术

无线搜索已成为一个新的研究、开发领域.并且它主要用到信息检索、人工智能、数据挖掘、自然语言处理、排序算法等多领域的理论和技术.此外,它拥有大量的用户,有很好的经济价值,所以引起了世界各国计算机科学界和信息产业界的高度关注,目前的研究、开发十分活跃,并出现了很多值得注意的动向.     

并行算法软件库PASL

本文介绍了并行算法软件库ＰＡＳＬ。ＰＡＳＬ库运行在具有共享存储的多处理机上，它可以用于科学工程计算和仿真。     

多幅图像显示时色彩压缩的聚类统计算法

在计算机上，同屏显示多幅彩色图像会出现明显的失真（即色彩损失）．特别是两幅图像色调差别较大时（如一幅暖色调，一幅冷色调），失真现象更为严重．为了克服这一缺陷．本文在参考Ｋ均值聚类算法的基础上，优化了初始聚类中心，提出了色彩压缩的聚类统计算法．本算法简单实现较为方便，克服了Ｋ均值算法对色彩压缩不均衡及彩色失真度大的缺点．且不需经过多次迭代即可得到令人满意的效果，压缩时间短．     

泛Loeb可测集的S-饱和性

在 K-饱和的非标准模型中,研究了泛 Loeb 可测集 m(A),pns(~*X),cpt(~*X),fin(~*X),ns(~*X)的 S-饱和性.当 A 是紧致 Hausdorff 空间 X 的子集时,得到了 st~(-1)(A)是标准集的充分条件.     

绝缘栅PMOS的SUPREM—SEDAN联机模拟研究

本文分析及研究了作者对绝缘栅ＰＭＯＳ场效应结构所进行的ＳＵＰＲＥＭ—ＳＥＤＡＮ联机模拟．重点在衬底电阻率（掺杂浓度）与ＭＯＳ结构阈值电压之间的定量关系上得到了与实验完全一致的结果．同时，定量地描述了栅氧层中电离电荷的分布及其行为．揭示了上述效应的机理．     

线性分式规划的多项式算法

Charnes—Cooper提出了一种线性分式规划的算法。本文在此基础上证明了线性分式规划与一种特定的线性规划等价。将Karmarkar算法用于该线性规划,我们得到了线性分式规划的多项式算法。     

基于图像分割应用于临床上检测HP的一种快速算法

研究了利用图像分割技术,去辨别染色后的胃部切片是否有HP(Helicobacter Pylori幽门螺旋菌),并给出了一种二维直方图与FCM(Fuzzy Clustering模糊聚类)相混合的图像分割方法.运用色彩特征抽取技术,可以更加精确和快捷地识别HP.     

Influence of hydrochlorothiazide on the pain threshold and on the antinociceptive activity of morphine,in rats

Summary Hydrochlorothiazide, acutely injected in rats, has a weak analgesic activity per se and potentiates and prolongs the antinociceptive effect of morphine.This work was supported in part by grants from Consiglio Nazionale delle Ricerche, and by Ministero della Pubblica Istruzione, Roma.     

长春市城郊无公害农业土壤环境中As含量状况调查研究

通过对长春市城郊无公害农业土壤环境中As含量水平调查,并进行了相对于无公害农作物产地环境质量标准中有关As的污染性评价,得出长春市城郊农业土壤环境中As的含量水平状况。长春市城郊无公害农业土壤环境中As含量存在不均衡性;浓度范围在4 12μg/g～18 60μg/g之间,平均值为12 17μg/g;污染呈现出从西南至东北的带状趋势;以《农产品安全质量无公害蔬菜产地环境要求》中GB/T18407 1-2001规定的As的质量标准作为评价标准进行评价,长春市城郊农业土壤环境中As的标准污染指数均小于1,属于未受As污染的土壤类型。图3,表2,参6。