Comparative and statistical analysis of nAChR sequences: An <Emphasis Type="Italic">ab initio</Emphasis> approach to the origin of molecular discrimination

Compared with traditional structure-based approaches for the identification of species-specific ligands, the ab initio approach, based on large-scale protein sequences from different species, has been used to locate specific sites that may be important to the molecular selectivity of species. Statistically significant differences in the distribution of residues in different species and differences in the physicochemical properties of residue-specific sites may largely account for species selectivity. The nicotinic acetylcholine receptor (nAChR), an important neuro-receptor with significantly different ligand selectivity in different species, was used to test our method. Because of the lack of nAChR structural information, the mechanism of ligand discrimination is unclear which hinders attempts at novel molecular design. In this study, the specific site residues 186 and 189 in the principal subunits and residues 34, 55, 56, 57, 106 and 112 in complementary subunits of nAChR were identified by applying our method with stringent statistical cutoffs. These sites were predicted to contribute to ligand selectivity and this result coincides well with the known experimental data.     

区域生态经济功能区划研究回顾与展望

生态经济功能区划是生态科学和经济科学领域的一项重要研究内容,它对识别区域的生态经济特征,制定区域社会经济发展战略,实现区域可持续发展具有深远的指导意义.文章回顾了我国生态经济功能区划的发展历程,系统总结、分析和评价了生态经济区划的研究方法,并对生态经济功能区划研究热点和发展趋势进行了展望.     

基于特征变换的高光谱图像压缩快速矢量量化算法

矢量量化能够得倒良好的压缩效果但有着计算复杂度高的缺点.提出了一种基于特征变换的快速矢量量化算法来压缩高光谱图像.该算法利用了高光谱高维空间大都是空的,可以用较低的子空间来表示这一特点.在较低维数的子空间进行矢量量化会大大降低运算的复杂度.所提出的算法在获得和经典的扩展劳埃德算法效果相当的情况下,大大降低了运算时间.     

信息化条件下地方高校实验室建设发展趋势分析

根据当前地方高校实验室建设现状,对信息化条件下实验室建设发展趋势进行了分析,介绍了在信息技术条件下高等院校实验室建设参考方向,提出今后实验室建设的几点建议。     

竹缕舟蛾幼虫及蛹空间格局的研究

采用聚集度指标法和回归分析法,对竹缕舟蛾幼虫在竹林中的空间格局进行测定,结果表明,竹缕舟蛾幼虫及蛹在竹林中均为聚集分布,分布的基本成分是个体群;同时用刀切法对聚集度指标进行估计,给出其估计区间。     

Tax Evasion: Models with Self-Audit

Different from traditional tax audit, supervision with self-audit is a combination of audit by the taxpayer himself and audit by the tax authority. This paper mainly studies a taxpayer＇s optimal policy of tax evasion under supervision with self-audit and its related properties, in order to deduce some effective suggestions and theoretical bases to restrain tax evasion. Assuming that only a certain proportion of evaded tax can be discovered when the audit is executed, the authors first formulate a static model with self-audit. This model is divided into two stages. At the first stage, taxpayers declare their taxes, then the tax authority chooses audit objects, based on a known probability, and announces the result; if the taxpayer is chosen, he will enter the second stage, during which he has a chance to pay the evaded tax and the corresponding late fees and then is audited by the tax authority. The authors show the existence and uniqueness of the optimal amount of tax evasion at the first stage and the optimal proportion to self-expose at the second stage. The authors also discuss the related properties of the interior solution, and do elasticity analyses on some parameters. Besides, the authors extend the static model into the corresponding two-period model, and study the existence and uniqueness of the solution of the extended model. Finally, under the assumption that tax evasion can only be discovered with a certain probability when the audit is executed, the authors formulate another static model with self-audit and investigate its properties.     

Vanadyl ions binding to GroEL （HSP60） and inducing its depolymerization

Several vanadium compounds have been known for the hypoglycemic and anticancer effects. However, the mechanisms of the pharmacological and toxicological effects were not clear. In this work, we in- vestigated the potential targets of vanadium in mitochondria. Vanadyl ions were found to bind to mi- tochondria from rat liver with a stoichiometry of 244±58 nmol/mg protein and an apparent dissocia- tion constant (Kd) of (2.0±0.8)×10·16 mol/L. Using size exclusion chromatography, a vanadium-binding protein was isolated and identified to be the 60-kDa heat shock protein (HSP60) by mass spectrometry analysis and immunoassays. Additionally, binding of vanadyl ions was found to result in depolymeri- zation of homo-oligomeric HSP60 (GroEL). HSP60 is an indispensable molecular chaperone and in- volved in many kinds of pathogenesis of inflammatory and autoimmune diseases, e.g. type 1 diabetes. Our results suggested that HSP60 could be a novel important target involved in the biological and/or toxicological effects of vanadium compounds.     

导流方案决策因素量化的层次分析法

建立了导流方案决策技术因素的层次分析模型，用层次分析法，将比较判断用比率标度量化，构造判断矩阵，经计算和检验，把影响工程导流方案决策的各因素的影响程度量化，构成各因素对导流方案决策影响程度的量化指标体系，使导流方案的决策环境明朗化，为导流方案的决策分析提供了新方法。