建国初期中国共产党执政文化资源的整合与构建

建国初期,中国共产党通过对思想意识形态的整合以及文化科学教育事业的改革与建设,构建了执政的文化资源,奠定了其执政的思想文化基础.中国共产党在建国初期整合与构建执政文化资源的工作取得了巨大成就,其经验教训,至今仍有启迪意义.     

Beta算子关于导数只具有第1类间断点函数的同时逼近

利用概率论中中心极限定理研究了Beta算子及其导数对导数只具有第1类间断点函数类的同时逼近问题,得到了误差的点态的估计.     

地面气象测报业务软件瑕疵的改进-以风极值时间缺测的处理为例

在地面气象观测数据审核工作中发现,自动气象站采集的风极值在24时00分出现“时间缺测”的概率比较大,需要数据审核员按照技术规范逐一进行处理。地面气象测报业务软件的新版本应当考虑这一问题,以提高数据处理的有效性,并可弥补自动气象站监控软件的不足。     

基于系统动力学理论建模的教育投资、经济增长和就业问题的研究

运用系统动力学的理论、方法构建模型,对教育投资、经济增长与就业问题进行了模拟,提出应加大教育投资力度,提高国民教育水平,将巨大的人口压力转化为巨大的人力资本优势,同时也必须兼顾由于人口总量以及其他因素导致的巨大的就业压力问题,在教育投资与固定投资之间保持合理的比例关系,以促进经济的持续、适度发展,为政府决策提供参考和依据。     

一类3-紧优双环网无限族

到给定顶点数的双环网的最小直径是图论和计算机工作者广泛研究的问题。虽然大多数双环网可以达到紧优,但仍然有一部分双环网不能达到。本文给出了一类3-紧优的双环网无限族。     

基于关系契约的研发联盟收益分配问题

在关系契约框架下研究研发联盟的收益分配问题.结果表明,研发联盟一次性合作的收益分配方案应遵循绝对优势原则,即合作各方应能够得到与自身贡献相匹配的合理收益;而重复合作收益分配应遵循相对优势原则,即根据相对成本和相对效率确定收益分配率,应给予相对劣势成员比短期合作中更高的收益分配比例,虽然该比例仍低于相对优势成员.这些研究结论可用来修正研发联盟收益分配正式契约条款,有助于克服成员的背约冲动,维护研发联盟的长期稳定.     

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

Systematic genetic interaction studies have illuminated many cellular processes. Here we quantitatively examine genetic interactions among 26 Saccharomyces cerevisiae genes conferring resistance to the DNA-damaging agent methyl methanesulfonate (MMS), as determined by chemogenomic fitness profiling of pooled deletion strains. We constructed 650 double-deletion strains, corresponding to all pairings of these 26 deletions. The fitness of single- and double-deletion strains were measured in the presence and absence of MMS. Genetic interactions were defined by combining principles from both statistical and classical genetics. The resulting network predicts that the Mph1 helicase has a role in resolving homologous recombination-derived DNA intermediates that is similar to (but distinct from) that of the Sgs1 helicase. Our results emphasize the utility of small molecules and multifactorial deletion mutants in uncovering functional relationships and pathway order.     

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.     

The human genome and understanding of common disease: present and future technologies

The study of candidate genes over the past three decades has yielded notable successes in common-disease genetics. During this time, however, interpretation of genetic association studies has been hampered by the use of clinical cohorts of inadequate power and insufficient information on genetic variation in candidate genes. The unavailability of highthroughput and low-cost genotyping technologies has also limited the scope of complex-disease genetic studies. More recently, however, the sequencing and characterization of variation within the human genome has revolutionized genetic studies and enabled full genome-wide scans for genes associated with disease. The identification of disease-associated (causative) genes has illuminated disease mechanisms. The translation of this knowledge into direct clinical benefit in diagnosis, prognosis and therapy for an individual’s disease still remains a challenge. Received 11 September 2006; received after revision 17 December 2006; accepted 18 January 2007