角域中的二维冻结干燥问题

利用现有的一维问题精确解直接构造某些二维问题的近似解。以角域为例的研究结果表明，这样构造某些二维问题的近似解形式简单，又有足够的精确度，可应用于工程实际。     

CIMS中的工程信息管理

在工程信息管理模式方面提出了使用动态库、受控库和静态库分别管理处于不同阶段的目标数据的管理办法；在管理机制方面讨论了基于这三类库的工程信息管理系统，包括组成该系统的结构管理、设计过程管理、版本管理和计划调度软件，以及支撑上述软件的软件工具．该系统不仅支持工程中的顺序设计，还支持并行设计     

直流输电系统的暂态仿真

应用结构矩阵法建立了双桥换流站的数学模型．为提高计算精度，提出以余弦外推公式预报换相电压，以抛物线拟合阀电流以判断阀的截止时刻，采取变步长与定步长相结合的方法来简化处理因阀通断造成的间断点．还讨论了交直流电网的接口问题．算例表明本方法是可行的．     

按灵敏度与传递函数设计的二自由度控制方法

根据灵敏度函数的概念，利用模型参考自适应的原理，提出了按系统灵敏度函数与系统传递函数独立设计的二自由度控制方案。论证了二自由度控制原理，并推导了实现这一控制的条件，理论研究和实验结果表明，将这一控制思想运用于参数大范围变化的控制系统设计时，能极大增强系统的鲁棒性。     

PDP废电子浆料中银的回收及其含量分析

为了回收PDP(等离子显示屏)废电子浆料中的银,实验采用X荧光光谱仪、元素分析仪以及佛尔哈德法(Volhard法)分析其中元素组成及其含量,得到PDP废电子浆料中的银含量为86.20%。采用熔融法回收银,并通过正交实验,确定样品中银回收的最佳实验条件为:还原温度400℃,保温时间3 h,熔融温度1 000℃。银回收率为99.69%,纯度为99.74%。通过XRD分析验证说明回收银产品中含银元素。这种银回收方法工艺简单,环境污染小,易于工业化生产。     

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci

We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft palate (NSCL/P) using data from the two largest genome-wide association studies published to date. We confirmed associations with all previously identified loci and identified six additional susceptibility regions (1p36, 2p21, 3p11.1, 8q21.3, 13q31.1 and 15q22). Analysis of phenotypic variability identified the first specific genetic risk factor for NSCLP (nonsyndromic cleft lip plus palate) (rs8001641; P(NSCLP) = 6.51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16).     

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

The amyloid precursor protein (APP) is part of a larger gene family, which has been found to form homo- or heterotypic complexes with its homologues, whereby the exact molecular mechanism and origin of dimer formation remains elusive. In order to assess the cellular location of dimerization, we have generated a cell culture model system in CHO-K1 cells, stably expressing human APP, harboring dilysine-based organelle sorting motifs [KKAA-endoplasmic reticulum (ER); KKFF-Golgi], accomplishing retention within early secretory compartments. We show that APP exists as disulfide-bonded dimers upon ER retention after it was isolated from cells, and analyzed by SDS-polyacrylamide gel electrophoresis under non-reducing conditions. In contrast, strong denaturing and reducing conditions, or deletion of the E1 domain, resulted in the disappearance of those dimers. Thus we provide first evidence that a fraction of APP can associate via intermolecular disulfide bonds, likely generated between cysteines located in the extracellular E1 domain. We particularly visualize APP dimerization itself and identified the ER as subcellular compartment of its origin using biochemical or split GFP approaches. Interestingly, we also found that minor amounts of SDS-resistant APP dimers were located to the cell surface, revealing that once generated in the oxidative environment of the ER, dimers remained stably associated during transport. In addition, we show that APP isoforms encompassing the Kunitz-type protease inhibitor (KPI) domain exhibit a strongly reduced ability to form cis-directed dimers in the ER, whereas trans-mediated cell aggregation of Drosophila Schneider S2-cells was isoform independent. Thus, suggesting that steric properties of KPI-APP might be the cause for weaker cis-interaction in the ER, compared to APP695. Finally, we provide evidence that APP/APLP1 heterointeractions are likewise initiated in the ER.     

Banach空间中具误差的Ishikawa和Mann迭代序列的强收敛定理

在新的限制条件下，通过引入序列不等式证明了具误差的Ishikawa和Mann迭代序列的强收敛定理，并得出了Ishikawa和Mann迭代的强收敛定理．     

Mechanisms of endothelial cell migration

Cell migration plays a central role in a variety of physiological and pathological processes during our whole life. Cellular movement is a complex, tightly regulated multistep process. Although the principle mechanisms of migration follow a defined general motility cycle, the cell type and the context of moving influences the detailed mode of migration. Endothelial cells migrate during vasculogenesis and angiogenesis but also in a damaged vessel to restore vessel integrity. Depending on the situation they migrate individually, in chains or sheets and complex signaling, intercellular signals as well as environmental cues modulate the process. Here, the different modes of cell migration, the peculiarities of endothelial cell migration and specific guidance molecules controlling this process will be reviewed.