Wnt-beta-catenin signaling initiates taste papilla development

Fungiform taste papillae form a regular array on the dorsal tongue. Taste buds arise from papilla epithelium and, unusually for epithelial derivatives, synapse with neurons, release neurotransmitters and generate receptor and action potentials. Despite the importance of taste as one of our five senses, genetic analyses of taste papilla and bud development are lacking. We demonstrate that Wnt-beta-catenin signaling is activated in developing fungiform placodes and taste bud cells. A dominant stabilizing mutation of epithelial beta-catenin causes massive overproduction of enlarged fungiform papillae and taste buds. Likewise, genetic deletion of epithelial beta-catenin or inhibition of Wnt-beta-catenin signaling by ectopic dickkopf1 (Dkk1) blocks initiation of fungiform papilla morphogenesis. Ectopic papillae are innervated in the stabilizing beta-catenin mutant, whereas ectopic Dkk1 causes absence of lingual epithelial innervation. Thus, Wnt-beta-catenin signaling is critical for fungiform papilla and taste bud development. Altered regulation of this pathway may underlie evolutionary changes in taste papilla patterning.     

浅谈大学生择业与职业生涯规划

阐述了职业生活和大学生职业生涯规划的重要性,论述了择业方式对大学生择业的影响,分析了大学生择业价值取向的特点。     

听觉线索引导大鼠空间定位

运用Morris水迷宫实验模式,研究听觉线索在大鼠进行空间定位时的作用.结果显示:听觉线索引导组和对照组动物在4 d内寻找平台的时间和错误率均显著下降.但与对照组动物相比,听觉线索引导组动物寻找隐藏平台的时间和错误率均较低,2组之间具有显著性差异(P<0.05).对动物的轨迹分析发现,听觉线索引导组和对照组动物在水池边缘区域分配的时间不同,提示2组动物寻找平台所用的策略不同.实验结果提示,大鼠能够利用单独的声音线索进行空间定位.     

对高校图书馆参与校园文化建设的探讨

阐述了校园文化与高校图书馆的关系,指出了图书馆参与校园文化建设的途径,提出了图书馆参与校园文化建设的建议。     

扩展Meadows模型分析Ad Hoc网络路由协议安全性

目前,Ad hoc网络安全路由协议缺乏有效的形式化分析方法.通过添加基于图论的路由描述和分析方法,文章扩展了Meadows模型的分析能力.使用扩展后的Meadows模型对Ad hoc网络安全路由协议Ariadne进行了分析,分析结果显示Ariadne协议存在产生虚假路由的漏洞,从而也说明了扩展后的Meadows模型能够用于Ad hoc网络安全路由协议的安全性分析.     

Quantale上代数余核的一点注记

研究了代数余核的某些性质，同时亦探讨了代数余核与子Quantales之间的联系．     

世界经济层内进化浅论

本文将物理系统层内进化扩展到世界经济系统中去，通过对世界经济循环结构与物理系统进化的层次结构关系的探讨，论述了世界经济周期的特征及经济周期的熨平作用。     

论全球化视野下的民族文化整合与发展

经济全球化的兴起 ,不仅使生产要素在全球得以配置 ,也使文化多元化成为各民族文化发展的平台。无疑 ,2 1世纪人类文化交往的空间会进一步扩大 ,然而 ,由于各民族文化间的差异 ,文化整合问题日益凸现。因此 ,应当以创新的观点对待中西文化 ,以自觉的心态建构现代文化形态 ,实现民族文化的整合与发展。     

Samples Selection for Artificial Neural Network Training in Preliminary Structural Design

An artificial neural network (ANN) is applied in the preliminary structural design of reticulated shells. Major efforts are made to enhance the generalization ability of networks through well-selected training samples. Number-theoretic methods (NTMs) are adopted to generate samples with low discrepancy, i.e.uniformly scattered in the domain, where discrepancy is a quantitative measurement of the uniformity. The discrepancy of the NTM-based sample set is 1/6-1/7 that of samples with equal spacing. In a case study,networks trained by NTM-based samples are compared with those trained by equal-spaced samples in generalizing performance. The results show that both the computational precision and stability of the former ANNs are more satisfactory than those of the latter. It is concluded that the flexibility of ANNs in generalizing can be effectively increased by use of uniformly distributed training samples rather than simply piling data.More reliable uniformity should be obtained, however, through NTMs instead of equal-spaced samples.     

一类自适应松弛算法的算法模型

对于一类自适应松弛算法,本文提出了一个算法模型。在一些通常的假定下,证明了该模型生成的序列的收敛性定理。