Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.

A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin gamma1 heavy chain was cloned from total cellular DNA. Electron microscopic and nucleotide sequencing studies showed that the three protein domains and the hinge region are encoded in separate DNA segments.     

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.     

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats

Summary Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.     

Microtubule motors in mitosis

The mitotic spindle uses microtubule-based motor proteins to assemble itself and to segregate sister chromatids. It is becoming clear that motors invoke several distinct mechanisms to generate the forces that drive mitosis. Moreover, in carrying out its function, the spindle appears to pass through a series of transient steady-state structures, each established by a delicate balance of forces generated by multiple complementary and antagonistic motors. Transitions from one steady state to the next can occur when a change in the activity of a subset of mitotic motors tips the balance.     

某型航空发动机对插板式进气畸变的响应

为得到较为准确的发动机对进气畸变的稳定性响应模型,首先分析了由实验所得到的某型航空涡扇发动机进口扰流插板产生的稳态总压畸变和紊流分布。相对于压气机转子进口,将周向分布的稳态总压畸变和截面脉动压力处理成为一组不同频率的压力激励波形分布。通过频谱分析得到:在发动机失稳前,稳态畸变形成的波形频率最低,幅值最大,是引起发动机失稳的主要原因。对该组合畸变激励波用一阶响应模型进行动态修正并使用平行压气机分析模型,得到了经修正的压气机喘振边界和得到改善的发动机进气畸变响应模型。最后分别计算了高、低压压气机逐步失稳的工作点移动过程。结果表明:与压气机出口实验失稳波形十分接近,该模型准确可行。     

局部固支功能梯度板的横向弯曲研究

研究了局部固支功能梯度方板在横向均布载荷作用下的静力学问题。假设功能梯度材料由陶瓷和钢组成，材料弹性模量设计为沿着板的厚度方向按照幂指数形式连续变化，功能梯度方板的四个边均为局部固支，应用Kirchhoff薄板理论和虚功原理推导了板的静力学有限元方程。另分别考虑了各边50%固支和25%固支两种情况，在板材料为纯陶瓷和纯钢时，将所得结果与ANSYS软件结果对比，验证了所建模型的准确性。最后，重点分析了梯度指数对板面和边界最大挠度的影响。结果表明梯度指数和固支范围是决定最大挠度的关键参数，其中固支范围对边界上最大挠度的影响更大。