郑洛新国家自主创新示范区信息协同研究

在信息生态环境下,信息资源日益成为一种战略性资源。本文在郑洛新国家自主创新示范区背景下,运用信息协同视角分析对示范区发展的影响因素,并最终得出信息协同之于"郑洛新"的有益影响。文章最后以郑洛新示范区如何构建信息协同模式为总结,提出了同构管理信息系统、智能云平台建设、新型数据管理技术应用等相关建议。     

医用细菌纤维素的制备及其细胞相容性

以椰汁作为基本的碳源和生长因子来源,通过添加成分明确的乙醇及酵母膏作为补充碳源和氮源,并补加相应的微量元素,获得了成分简单、明确的医用细菌纤维素培养基;该培养基各成分含量相对稳定,提高了细菌纤维素的发酵速率和产量,所获得的产物厚度可满足不同的医用需求.将碱液分别与十二烷基硫酸钠(SDS)、超声波及乙醇联用对发酵产物进行纯化处理.结果表明:碱液与SDS联用时纯化效果最好;纯化所得样品的杂质N含量低于检测限,透光率高,在可见光范围内与活体角膜透光率相近,L929细胞相容性良好.     

<Emphasis Type="Italic">Yersinia pseudotuberculosis</Emphasis> supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling

Adaptive immunity critically contributes to control acute infection with enteropathogenic Yersinia pseudotuberculosis; however, the role of CD4⁺ T cell subsets in establishing infection and allowing pathogen persistence remains elusive. Here, we assessed the modulatory capacity of Y. pseudotuberculosis on CD4⁺ T cell differentiation. Using in vivo assays, we report that infection with Y. pseudotuberculosis resulted in enhanced priming of IL-17-producing T cells (Th17 cells), whereas induction of Foxp3⁺ regulatory T cells (Tregs) was severely disrupted in gut-draining mesenteric lymph nodes (mLNs), in line with altered frequencies of tolerogenic and proinflammatory dendritic cell (DC) subsets within mLNs. Additionally, by using a DC-free in vitro system, we could demonstrate that Y. pseudotuberculosis can directly modulate T cell receptor (TCR) downstream signaling within naïve CD4⁺ T cells and Tregs via injection of effector molecules through the type III secretion system, thereby affecting their functional properties. Importantly, modulation of naïve CD4⁺ T cells by Y. pseudotuberculosis resulted in an enhanced Th17 differentiation and decreased induction of Foxp3⁺ Tregs in vitro. These findings shed light to the adjustment of the Th17-Treg axis in response to acute Y. pseudotuberculosis infection and highlight the direct modulation of CD4⁺ T cell subsets by altering their TCR downstream signaling.     

地下钢筋混凝土岔管围岩稳定及结构数值分析

以国内某抽水蓄能电站的钢筋混凝土岔管工程为例,从围岩开挖支护、围岩与衬砌相互作用和钢筋混凝土结构等方提出了围岩、混凝土等材料的数值模拟方法,通过三维有限元线性和非线性计算,分析研究了地下钢筋混凝土岔管在施工、运行等工况下,围岩、衬砌结构的应力与变形,以及混凝土岔管结构配筋和配筋后应力、裂缝开展等问题.结果表明：在开挖阶段由于地应力释放在主、岔洞交叉处会产生拉应力,塑性区开展较深;正常运行工况在内水压力作用下岔管结构大部分区域存在拉应力,裂缝较大;检修工况在外水压力作用下仅在主、岔管交叉处存在拉应力区,裂缝较小;结构配筋时,轴向配筋应该由外水作用的工况来控制,环向配筋由内水作用为主的工况来控制.     

1000 mm2 cross-section wire a led four tension exhibition put to traction practice

文章介绍了宁东一山东±660 kV直流输电示范工程(晋4标段)1 000 mm2大截面导线一牵四张力展放施工中,使用4个转向滑车转向布置牵引场的实践过程及施工中的注意事项.     

小学应用题教学的一般技巧

本文总结了小学应用题教学中的一般规律,只要我们能领会它的规律,遵循小学生思维发展的规律和认知特点,在教学中结合本班学生基础能力的实际情况,灵活变通地开展教学活动,定能培养起学生的学习兴趣,有效地提高学生解答应用题的能力.