Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.

Interleukin-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1-3). IL-2 is, however, not the sole T-cell growth factor, nor does it act exclusively on T cells, also promoting growth of NK cells and differentiation of B cells. A role for IL-2 in T-cell development has been postulated but remains controversial. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.     

分形插值函数与分形平移曲面

本文在R~3中构造一平移曲面,使其为通过N+1个给定点的xog坐标面上一矩形域上的连续分形插值函数的图,并为某个双曲迭代函数系的吸收子,进而讨论了与该迭代函数系相关的码空间、抽象动力系和分形插值函数的动差,而且就一类特殊情况讨论了分形曲面的分形维数.最后,我们讨论了与一类非双曲迭代函数系相关的分形插值函数、分形曲面.     

Purealidin A,a new cytotoxic bromotyrosine-derived alkaloid from the Okinawan marine spongePsammaplysilla purea

Summary A new bromotyrosine-derived alkaloid with antileukemic activity, purealidin A (5), has been isolated from the Okinawan marine spongePsammaplysilla purea and its chemical structure elucidated on the basis of the spectroscopic data.     

富马酸烷·3-PG酯抗氧化和防霉性能

在对没食子酸丙酯 (PG)的抗氧化活性、富马酸酯的防霉活性进行分析和预测的基础上 ,对其分子结构进行改造 ,设计出一类新型化合物———富马酸烷·3-PG酯 .对五种目标产物进行抗氧化和防霉性能测试的结果表明 ,它们均同时具有与没食子酸丙酯相当的抗氧化性能和与富马酸二甲酯相当的防霉性能 ,打破了以往抗氧化剂和防霉剂需分别添加的传统     

高粘度十二烯基琥珀酸淀粉钠理化性质的研究(Ⅱ)——颗粒形貌和乳化性质

原玉米淀粉经十二烯基琥珀酸酐（DDSA）酯化后，颗粒形貌发生变化。经研究认为：化学反应首先发生在淀粉颗凿表面的无定形区；酯化后淀粉的乳化能力明显增强，不同取代度产品的亲水亲油平衡（HLB）值均大于10，表明它为亲水型乳化稳定剂。     

氟化钠对洋葱根尖细胞有丝分裂的影响

用不同浓度的氟化钠溶液 ,分别处理洋葱根尖 ,发现在有丝分裂的细胞中 ,出现了滞后染色体、染色体桥和多极化现象。有些细胞中还出现了微核。同时 ,在实验中还观察到 ,随着溶液浓度的增加和染毒时间的延长 ,细胞增殖率下降 ,有丝分裂指数递减     

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis.

Low-molecular-weight GTP-binding proteins are strong candidates for regulators of membrane traffic. In yeast, mutations in the sec4 or ypt1 genes encoding small GTP-binding proteins inhibit constitutive membrane flow at the plasma membrane or Golgi complex, respectively. It has been suggested that membrane fusion-fission events are regulated by cycling of small GTP-binding proteins between a membrane-bound and free state, but although most of these small proteins are found in both soluble and tightly membrane-bound forms, there is no direct evidence to support such cycling. In rat brain a small GTP-binding protein, rab3A, is exclusively associated with synaptic vesicles, the secretory organelles of nerve terminals. Here we use isolated nerve terminals to study the fate of rab3A during synaptic vesicle exocytosis. We find that rab3A dissociates quantitatively from the vesicle membrane after Ca2(+)-dependent exocytosis and that this dissociation is partially reversible during recovery after stimulation. These results are direct evidence for an association-dissociation cycle of a small GTP-binding protein during traffic of its host membrane.     

在UBBE框架下考虑不肯定的上界的估计方法

对目前的ＵＢＢＥ模型进行了适当的推广，使在解决估计问题时可以考虑那些可能是误差上界的数值，并在此基础上提出了一种方法，能够通过对估计精度和可靠性进行合理的权衡确定所需估计值，实际案例研究结果表明所提方法能够较好地解决估计精度和可靠性之间的矛盾。     

牡丹与寒梅:以两种花卉阐释唐宋士人的差异

在中国古代,历来有花卉鸟兽抒情明志的传统。在特定历史时期中,某种自然物象同特定的情感和意义之间建立了相对稳固的关系,经过社会的认同,物象便转化为人的情感符号而失去了自身客观性质的特征而成为时代的一种标志。牡丹与寒梅就是唐宋两代士人给予充分观照的审美对象,前者艳绚丽、神采外放,代表了唐代建功立业、开张扬厉的时代精神;后者瞿瘦淡雅,外枯中膏,可与宋人淡泊收敛,质朴深微的心态相契合。唐人爱牡丹,宋人重寒梅,从两种花卉的分析中,可对唐宋的时代精神加以阐释。