The regulatory role of phosphodiesterase in adenosine cyclic 3′,5′-monophosphate mediated ACTH action

Résumé Le désoxycholate de soude inhibe fortement l'activité de la phosphodiestérase surrénalienne du rat. Par contre, l'administration de l'ACTH in vivo augmente cette activité en présence du déoxycholate. In vitro, chez le rat traité préalablement par le l'ACTH, cette activité est moins inhibée par le désoxycholate dans la fraction particulière comme dans la fraction surnageante. L'action de l'ACTH joue donc un rôle régulateur de la phosphodiestérase.     

Annexin II light chain regulates sensory neuron-specific sodium channel expression

The tetrodotoxin-resistant sodium channel Na(V)1.8/SNS is expressed exclusively in sensory neurons and appears to have an important role in pain pathways. Unlike other sodium channels, Na(V)1.8 is poorly expressed in cell lines even in the presence of accessory beta-subunits. Here we identify annexin II light chain (p11) as a regulatory factor that facilitates the expression of Na(V)1.8. p11 binds directly to the amino terminus of Na(V)1.8 and promotes the translocation of Na(V)1.8 to the plasma membrane, producing functional channels. The endogenous Na(V)1.8 current in sensory neurons is inhibited by antisense downregulation of p11 expression. Because direct association with p11 is required for functional expression of Na(V)1.8, disrupting this interaction may be a useful new approach to downregulating Na(V)1.8 and effecting analgesia.     

国际互联网技术与旅游业企业过程重组

信息技术、互联网、通讯技术的发展引起了整个旅游业的一场革命,正在深刻地改变着旅游业的经营、管理和运作模式。网络技术的出现则恰好给旅游业的加速发展、企业过程重组带来了新的机遇。文章集中分析了旅游业的信息特征、信息技术、互联网技术引起的旅游业的经营环境变化,提出了旅游服务供应链管理的概念。在此基础上,结合英特网技术在旅游业的功能,提出了旅游业的企业过程重组,建立虚拟旅游公司模式。     

吕梁山中南部地区农田害鼠调查研究

调查明确了山西省吕梁山中南部农田害鼠的种类和数量组成,明确了数量分布特点,本项研究为该区域害鼠综合治理对策的制定提供了科学依据.     

Pb污染对土壤动物群落结构的影响

应用Pb(NO3)2对土壤动物进行了污染模拟实验,共获得土壤动物1289个,隶属3门7纲.结果显示,Pb污染浓度直接影响土壤动物群落结构的变化.在获得的1289个土壤动物中,优势类群为弹尾目、前气门亚目和甲螨亚目,3个优势类群占土壤动物全捕量的78.2%,对动物群落结构起决定作用.随着Pb污染浓度的增加,土壤动物的类群数、个体数和多样性指数都呈现出明显的下降趋势.从实验结果看,蜱螨目和弹尾目是反映土壤Pb污染程度的敏感指示类群.     

贝叶斯规整化神经网络预测苯取代物的毒性

利用贝叶斯规整化神经网络(BRNN)研究了59种苯取代的环境毒性和分子结构的关系.建立了基于脂水分配系数和4种量子指数的QSAR环境毒性预测模型.结果表明:该模型的预测性能超过偏最小二乘法(PLS)和逐步线性回归方法,残差分析显示其稳定可靠,有望成为一种良好的苯取代物毒性的环境评价和预测的方法.     

The c-myc coding DNA sequences of cyprinids （Teleostei： Cypriniformes）： Implications for phylogeny

The family Cyprinidae is one of the largest fish families in the world, which is widely distributed in East Asian, with obvious difference in characteristic size among species. The phylogeneUc analysis of cyprinid taxa based on the functionally important genes can help to understand the speciation and functional divergence of the Cyprinidae. The c-myc gene is an important gene regulating individual growth. In the present study, the sequence variations of the cyprinid c-myc gene and their phylogenetic significance were analyzed. The 41 complete sequences of the c-myc gene were obtained from cyprinids and outgroups through PCR amplification and clone. The coding DNA sequences of the c-myc gene were used to infer molecular phylogenetic relationships within the Cyprinidae. Myxocyprinus asiaticus （Catostomidae）, Misgurnus anguillicaudatus （CobiUdae） and Hemimyzon sinensis （Homalopteridae） were assigned to the outgroup taxa. Phylogenetic analyses using maximum parsimony （MP）, maximum likelihood （ML）, and Bayesian retrieved similar topology. Within the Cyprinidae, Leuciscini and Barbini formed the monophyletic lineage respectively with high nodal supports. Leuciscini comprises Xenocyprinae, CuItrinae, East Asian species of Leuciscinae and Danioninae, Gobioninae and Acheilognathinae, and Barbini contains Schizothoracinae, Barbinae, Cyprininae and Labeoninae. Danio rerio, D. myersi and Rasbora trilineata were supposed to separate from Leuciscinae and Barbini and to form another lineage. The positions of some Danioninae species were still unresolved. Analyses of both amino acid variation with parsimony information and two high variation regions indicated that there is no correlation between variations of single amino acid or high variation regions and characteristic size of cyprinids. In addition, the species with smaller size were usually found to be basal within clades in the tree, which might be the results of the adaptation to the primitive ecology and survival pressure.     

机械产品功能建模及其求解策略的研究

简要阐述用于产品功能建模的标准功能基(SFB),并在SFB基础上完成产品功能建模;建立包括元功能层、功能对象层、行为层、结构组件层和结构关系层的功能求解模型,提出多层次柔性求解策略用于完成从功能到结构的映射;以实例对所提出的方法进行验证。