上皮植入性虹膜囊肿34眼治疗分析

分析评价上皮植入性虹膜囊肿发病机理和预防治疗方法。上皮植入性虹膜囊肿的预防最重要的是及时正确地处理角膜创口 ,治疗以微观手术切除效果最佳     

Choosing among competing econometric forecasts: Regression‐based forecast combination using model selection

Forecast combination based on a model selection approach is discussed and evaluated. In addition, a combination approach based on ex ante predictive ability is outlined. The model selection approach which we examine is based on the use of Schwarz (SIC) or the Akaike (AIC) Information Criteria. Monte Carlo experiments based on combination forecasts constructed using possibly (misspecified) models suggest that the SIC offers a potentially useful combination approach, and that further investigation is warranted. For example, combination forecasts from a simple averaging approach MSE‐dominate SIC combination forecasts less than 25% of the time in most cases, while other ‘standard’ combination approaches fare even worse. Alternative combination approaches are also compared by conducting forecasting experiments using nine US macroeconomic variables. In particular, artificial neural networks (ANN), linear models, and professional forecasts are used to form real‐time forecasts of the variables, and it is shown via a series of experiments that SIC, t‐statistic, and averaging combination approaches dominate various other combination approaches. An additional finding is that while ANN models may not MSE‐dominate simpler linear models, combinations of forecasts from these two models outperform either individual forecast, for a subset of the economic variables examined. Copyright © 2001 John Wiley & Sons, Ltd.     

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11. Chromosome 17 is rich in protein-coding genes, having the second highest gene density in the genome. It is also enriched in segmental duplications, ranking third in density among the autosomes. Here we report a finished sequence for human chromosome 17, as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Comparison of the orthologous regions reveals striking differences. In contrast to the typical pattern seen in mammalian evolution, the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequence has been remarkably stable. Moreover, although the human sequence has a high density of segmental duplication, the mouse sequence has a very low density. Notably, these segmental duplications correspond closely to the sites of structural rearrangement, demonstrating a link between duplication and rearrangement. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome.     

Vertebrate Smoothened functions at the primary cilium

The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal transduction. Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium. This ciliary expression is regulated by Hh pathway activity; Sonic hedgehog or activating mutations in Smo promote ciliary localization, whereas the Smo antagonist cyclopamine inhibits ciliary localization. The translocation of Smo to primary cilia depends upon a conserved hydrophobic and basic residue sequence homologous to a domain previously shown to be required for the ciliary localization of seven-transmembrane proteins in Caenorhabditis elegans. Mutation of this domain not only prevents ciliary localization but also eliminates Smo activity both in cultured cells and in zebrafish embryos. Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium.