Differential effects of the serotonin receptors on cultured rat cerebral cortical neurons

Effects of serotonin (5-HT) on cerebral cortical neurons were examined by patch clamp techniques. 5-HT produced a variety of responses such as outward (19/73 patches/neurons), slow inward (15/73 patches/neurons), fast inward (8/73 patches/neurons), and mixed currents (initially fast inward deflection followed by an outward response: 2/73 patches/neurons), with a latency of 12 sec, 15 sec, 0 sec, and 0 sec respectively, at a holding potential of −60 mV in whole-cell patches. The fast inward currents were again evoked by a selective 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (CPBG). In the cell-attached patch clamp configuration, 5-HT inside the patch pipette elicited single channel currents with slope conductances of 42 pS and 132 pS (4/42 patches/neurons). CPBG inside the patch pipette evoked inward single channel currents with a lower slope conductance of 41 pS (3/23 patches/neurons). In contrast, application of 5-HT or a 5-HT₂ receptor agonist, α-methyl-5-hydroxytryptamine-maleate, outside the patch pipette induced outward single channel currents with a major slope conductance of 140 pS (8/30 patches/neurons) or 135 pS (6/20 patches/neurons), respectively. These results indicate that the outward and fast inward currents may be mediated respectively by the 5-HT₂ receptor, which is coupled to a G-protein, and by the 5-HT₃ receptor, which contains the non-selective cation channel, and that the mixed type may be caused by both the 5-HT₂ and 5-HT₃ receptors. Received 27 September 1996; received after revision 4 November 1996; accepted 7 November 1996     

正常赖默—悌曼反应研究:超声波辐射与相转移催化合成方法

系统研究了正常及反常赖政－悌曼反应（NormalorAbnormalReliner－TiemannReavction，NRYorART）；研究了相转移住化方法和超声波辐射技术及其在正常Reliner—Tiemann（NRT）反应中的应用，从而使反应条件温和，效率增加，对邻比大，时间缩短，取得较好收效。     

广义Cury线搜索下一种新共轭梯度法及其全局收敛性

本文对无约束最优化问题：ｍｉｎｆ（ｘ），ｘ∈Ｒｎ，提出一种新的共轭梯度法．该算法中参数βｋ采用一种新取法，并结合广义Ｃｕｒｙ线搜索及ｎ步重新开始策略．在关于目标函数较弱条件假设下，证明了所给算法的全局收敛性．     

自动门限转速测量仪的设计

本文提出了自动门限测量转速的方法,同时介绍了采用8098单片机的A/D输入及PWM输出来实现自动门限,并且采用HSI及定时器实现转速测量的硬件电路及相应的软件设计方法.     

一种二氢苯并噻喃衍生物的新型合成法

介绍２－丁烯醛与苯硫酚之间的酸催化分子间一步成环反应，合成一种二氢苯并噻喃衍生物的新方法，产品收率高达８４％。     

新疆禾本科短命植物旱麦草的营养器官解剖学研究

本文报导了禾本科短命植物的旱麦草[Eremopyrum triticrurm(cmerth)Nevshi]具有特殊的解剖结构,茎在抽穗时,仍具有实心的薄壁组织,此特点在禾本科中生植物中罕见.在根、茎、叶中皆有大型薄壁细胞.茎、叶的表皮细胞及根中柱鞘内的薄壁细胞,它们的细胞壁均增厚,起着机械支持作用.叶的栅栏组织发达,由 2～3层栅栏细胞组成,等面叶,属于C_4植物型,根、茎仅有初生结构,其内部结构简单.     

用子波变换分析方法实时监测视觉诱发电位的潜伏期

诱发电位的实时监测在临床中有重要意义。本文提出利用多分辨率子波分析技术来实时监测视觉诱发电位的潜伏期。为克服随机噪声的影响，我们引入相邻响应的相关系数来修正所检测得的潜伏期的偏移，并应用前一次响应的波峰位置来决定当前的搜寻范围。实验表明，本方法能实时监测视觉诱发电位的潜伏期。     

切换系统的H∞动态输出反馈控制

研究一类具有扰动的线性切换系统在任意切换策略下的鲁棒H∞控制问题．基于线性矩阵不等式（LMI）、H∞控制理论和Lyapunov函数方法，给出了线性切换系统的H∞动态输出反馈控制器存在的充分条件和设计方法．由该方法设计的控制器不但使闭环系统渐近稳定且具有H∞性能界γ，最后用仿真算例验证了文中结论的有效性．