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排序方式: 共有228条查询结果,搜索用时 31 毫秒
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Ellinghaus E Ellinghaus D Stuart PE Nair RP Debrus S Raelson JV Belouchi M Fournier H Reinhard C Ding J Li Y Tejasvi T Gudjonsson J Stoll SW Voorhees JJ Lambert S Weidinger S Eberlein B Kunz M Rahman P Gladman DD Gieger C Wichmann HE Karlsen TH Mayr G Albrecht M Kabelitz D Mrowietz U Abecasis GR Elder JT Schreiber S Weichenthal M Franke A 《Nature genetics》2010,42(11):991-995
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Regional,individual and political determinants of FOMC members' key macroeconomic forecasts 下载免费PDF全文
We study Federal Open Market Committee members' individual forecasts of inflation and unemployment in the period 1992–2004. Our results imply that Governors and Bank presidents forecast differently, with Governors submitting lower inflation and higher unemployment rate forecasts than bank presidents. For Bank presidents we find a regional bias, with higher district unemployment rates being associated with lower inflation and higher unemployment rate forecasts. Bank presidents' regional bias is more pronounced during the year prior to their elections or for nonvoting bank presidents. Career backgrounds or political affiliations also affect individual forecast behavior. 相似文献
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Boris Strilić Tomáš Kučera Eckhard Lammert 《Cellular and molecular life sciences : CMLS》2010,67(19):3209-3218
The cardiovascular system developed early in evolution and is pivotal for the transport of oxygen, nutrients, and waste products
within the organism. It is composed of hollow tubular structures and has a high level of complexity in vertebrates. This complexity
is, at least in part, due to the endothelial cell lining of vertebrate blood vessels. However, vascular lumen formation by
endothelial cells is still controversially discussed. For example, it has been suggested that the lumen mainly forms via coalescence
of large intracellular vacuoles generated by pinocytosis. Alternatively, it was proposed that the vascular lumen initiates
extracellularly between adjacent apical endothelial cell surfaces. Here we discuss invertebrate and vertebrate cardiovascular
lumen formation and highlight the possible modes of blood vessel formation. Finally, we point to the importance of a better
understanding of vascular lumen formation for treating human pathologies, including cancer and coronary heart disease. 相似文献
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Hunt KA Smyth DJ Balschun T Ban M Mistry V Ahmad T Anand V Barrett JC Bhaw-Rosun L Bockett NA Brand OJ Brouwer E Concannon P Cooper JD Dias KR van Diemen CC Dubois PC Edkins S Fölster-Holst R Fransen K Glass DN Heap GA Hofmann S Huizinga TW Hunt S Langford C Lee J Mansfield J Marrosu MG Mathew CG Mein CA Müller-Quernheim J Nutland S Onengut-Gumuscu S Ouwehand W Pearce K Prescott NJ Posthumus MD Potter S Rosati G Sambrook J Satsangi J Schreiber S Shtir C Simmonds MJ Sudman M Thompson SD Toes R 《Nature genetics》2012,44(1):3-5
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Several habitat evaluation procedures have been developed for bighorn sheep. However, none of these procedures specifically addresses the Rocky Mountain subspecies nor analyzes both the quantity and quality of potential bighorn habitat with regard to minimum viable population (MVP) criteria. This bighorn habitat evaluation procedure combines (1) a quantitative assessment of bighorn range to determine if there are adequate quantities of resources to support an MVP of bighorn sheep, and (2) a qualitative assessment of a range to predict the probable density of bighorns the range can support. Extensive literature review, intensive bighorn research, and a modeling tool, pattern recognition (PATREC), facilitate critical analysis of proposed bighorn reintroduction sites. The resultant stepwise approach to bighorn habitat evaluation enhances the ability of wildlife biologists to make timely and accurate bighorn habitat assessments. 相似文献
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Pansuriya TC van Eijk R d'Adamo P van Ruler MA Kuijjer ML Oosting J Cleton-Jansen AM van Oosterwijk JG Verbeke SL Meijer D van Wezel T Nord KH Sangiorgi L Toker B Liegl-Atzwanger B San-Julian M Sciot R Limaye N Kindblom LG Daugaard S Godfraind C Boon LM Vikkula M Kurek KC Szuhai K French PJ Bovée JV 《Nature genetics》2011,43(12):1256-1261
Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci syndrome). We report somatic heterozygous mutations in IDH1 (c.394C>T encoding an R132C substitution and c.395G>A encoding an R132H substitution) or IDH2 (c.516G>C encoding R172S) in 87% of enchondromas (benign cartilage tumors) and in 70% of spindle cell hemangiomas (benign vascular lesions). In total, 35 of 43 (81%) subjects with Ollier disease and 10 of 13 (77%) with Maffucci syndrome carried IDH1 (98%) or IDH2 (2%) mutations in their tumors. Fourteen of 16 subjects had identical mutations in separate lesions. Immunohistochemistry to detect mutant IDH1 R132H protein suggested intraneoplastic and somatic mosaicism. IDH1 mutations in cartilage tumors were associated with hypermethylation and downregulated expression of several genes. Mutations were also found in 40% of solitary central cartilaginous tumors and in four chondrosarcoma cell lines, which will enable functional studies to assess the role of IDH1 and IDH2 mutations in tumor formation. 相似文献
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