提高投篮命中率初探

根据篮球教学的实践，对提高篮球投篮命中率问题，包括如何握球、瞄准点、投篮力量的运用、出手角度、出手速度、球的旋转、抛物线和入篮角等进行了剖析，为提高篮球教学和训练水平提供借鉴。     

西部大开发与投资主体结构调整

投资主体结构调整是投资结构调整的重点，也是我国全面实施经济结构调整中的重要组成部分，更是西部大开发的关键。西部地区要改变以前不合理的投资主体结构，需要从转变投资观念，改善投资环境，投资主体以政府投资为主转向多元化投资，投资客体从硬件力向软件等方面来调整投资结构。     

信息技术和教学方式的改革

主要阐述了信息技术给教学方式带来的深远影响，以及21世纪教师掌握和应用信息技术以辅助教学的必要性。     

新时期高校德育工作之我见

随着我国加入世贸组织，政治思想工作将面临新的机遇和挑战，因之，我们应从道德规范教育入手，运用法制教育手段，通过学生主体性的发挥，依托校园化氛围开展德育工作。     

互交式教学法在高校女生体育教学中的运用

根据普通高校女生心理特征,运用有关教育学理论,在高校女生体育教学中设计了互交式教学法,并与传统的教学方法进行了实验对比。     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

自治主体建模在海军战术仿真中的应用

多主体系统是分布人工智能和分布计算的交叉研究领域,也是普遍公认的研究和解决复杂自适应系统问题的一种有效途径,而武器装备体系对抗就是一类典型的复杂自适应系统问题.从分析实体模型层次和类型入手,利用作战主体刻画具有复杂作战行为的实体,提出一个作战主体模型框架,阐述作战单元、作战平台和装备的(装配或指挥控制)关联关系.     

美国室内设计师资质考试及其对我国的启示

介绍了美国国家室内设计师资格委员会（NCIDQ）关于专业室内设计师的概念，以及NCIDQ室内设计师资质考试的方式及类型，并从室内设计观、室内设计教育等方面分析了这一考试对我国的启示作用，指出室内设计师资质考试制度是公众利益的重要保障，是规范室内设计行业的必要措施．     

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. Using genome-wide synthetic genetic array mapping, we identified multiple TIF6 gain-of-function alleles that suppressed the pre-60S nuclear export defects and cytoplasmic mislocalization of Tif6 observed in sdo1Delta cells. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes. Thus, our data link defective late 60S ribosomal subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.