量子随机过程和非交换几何

随机过程的经典理论在经典力学中有重要的应用，如量子随机过程可以用来充当不可逆量子系统动力学模型，非交换即量子几何为量子随机结构的研究提供了框架。本书首先揭示了这两种数学过程之间的联系，把半群和完伞正性结合起来产生量子动力半群（QDS），将量子动力半群（QDS）与量子随机微分方程联系起来形成Evans-Hudson伸缩理论，进而将其推广到有界和无界系数情形。     

De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy

Early infantile epileptic encephalopathy with suppression-burst (EIEE), also known as Ohtahara syndrome, is one of the most severe and earliest forms of epilepsy. Using array-based comparative genomic hybridization, we found a de novo 2.0-Mb microdeletion at 9q33.3-q34.11 in a girl with EIEE. Mutation analysis of candidate genes mapped to the deletion revealed that four unrelated individuals with EIEE had heterozygous missense mutations in the gene encoding syntaxin binding protein 1 (STXBP1). STXBP1 (also known as MUNC18-1) is an evolutionally conserved neuronal Sec1/Munc-18 (SM) protein that is essential in synaptic vesicle release in several species. Circular dichroism melting experiments revealed that a mutant form of the protein was significantly thermolabile compared to wild type. Furthermore, binding of the mutant protein to syntaxin was impaired. These findings suggest that haploinsufficiency of STXBP1 causes EIEE.     

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kras is commonly mutated in colon cancers, but mutations in Nras are rare. We have used genetically engineered mice to determine whether and how these related oncogenes regulate homeostasis and tumorigenesis in the colon. Expression of K-Ras(G12D) in the colonic epithelium stimulated hyperproliferation in a Mek-dependent manner. N-Ras(G12D) did not alter the growth properties of the epithelium, but was able to confer resistance to apoptosis. In the context of an Apc-mutant colonic tumor, activation of K-Ras led to defects in terminal differentiation and expansion of putative stem cells within the tumor epithelium. This K-Ras tumor phenotype was associated with attenuated signaling through the MAPK pathway, and human colon cancer cells expressing mutant K-Ras were hypersensitive to inhibition of Raf, but not Mek. These studies demonstrate clear phenotypic differences between mutant Kras and Nras, and suggest that the oncogenic phenotype of mutant K-Ras might be mediated by noncanonical signaling through Ras effector pathways.     

MATLAB入门：第二版适用于初高级用户

本书简明扼要地介绍了MATLAB7．0系统。主要内容包括MATLAB命令；MATLAB程序设计；图形、图表、图像模板；方程求解函数和丰富多彩的快捷界面。这些命令对低版本和高版本的MATLAB同样适用。数学计算与文本、图形相结合，形成新颖完整的交互式文件是MAT—LAB7．0的新特点。书中介绍的内容既兼顾了初学者，又顾及了熟悉MATLAB早期版本的用户。     

Our Wonderland of Bureaucracy

这本书的作者贝克氏是一位律师和美国宪法学者,会做过美国的Solicitor-Gereral和众议院议员。他对於美国的政治向持保守的态度,因此对於近年行政机关职务及人员的扩充,以及这种扩充所引起的:所谓“布洛克拉西”(Bureaucracy)抱著怀疑和惧怕的心理。他很悄皮地值爱丽丝梦游奇境记作者百年纪念把这本描写美国“布洛克拉西”的书叫做布洛克拉西的奇境副标题为“对於美国联邦政府中之‘布洛克拉西’的发展及其对宪法的破坏之研究。”作者在村料的收集方面确是费过相当工夫的,我们在这本书中可以看到不少美国总统及国会议员的言论,最高法院判例…     

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in many age-related pathologies. Here we identify mtDNA deletions as a driving force behind the premature aging phenotype of mitochondrial mutator mice, and provide evidence for a homology-directed DNA repair mechanism in mitochondria that is directly linked to the formation of mtDNA deletions. In addition, our results demonstrate that the rate at which mtDNA mutations reach phenotypic expression differs markedly among tissues, which may be an important factor in determining the tolerance of a tissue to random mitochondrial mutagenesis.     

琼脂糖和卡拉胶在凝胶中的相互作用

研究了琼脂糖(Agarose)和卡拉胶(Carrageenan)共混物在水溶液中的相互作用力。通过测定不同组成的共混凝胶的力学性质,结果显示琼脂糖和卡拉胶之间的相互作用很小,仅存在相互之间的空间效应。但在大形变时,凝胶的性质类似理想溶液。纯凝胶的弹性模量(E)和浓度(C)的关系可以用E=kC~n表示,其中k值的大小意味着网络交联的强度,n与分子量有很大的关系。