Collaborative Project Management: A Systemic Approach to Heavy Equipment Manufacturing Project Management

Quite often over the last decade, heavy equipment manufacturers are trying to improve their project management performance with the use of effective project management methods. However, the challenges encountered aren’t isolated problems and a systemic approach is required. This paper exemplifies how a systemic approach can be applied to heavy equipment manufacturing project (HEMP) management, through of a multifaceted vision. The findings present in the paper are based on a two-year case study in a metallurgic equipment manufacturing enterprise in China. Based on the analysis of HEMP management problems and the contributions on systemic approach application in project management, the paper enriches existing theory by: (1) interpreting the HEMP management system with the top-down disassembly method; (2) developing the collaborative project management approach with a systems view highlighting the project characteristics management and inter-departmental collaboration; (3) making suggestions for systemic approach application in project management. For practitioners and researchers, the findings are particularly meaningful for manufacturing project management and systemic approach application.     

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.     

卫生部药品标准中药成方制剂中含反药药对成方制剂收载情况与分析

"十八反"、"十九畏"作为中医药领域传统的配伍禁忌,一直沿用至今,但由于临床不乏反药同用治疗某些疾病突显奇效的病案,其是否确属绝对配伍禁忌,是众多学者及临床医生关注的热点问题.<中华人民共和国卫生部药品标准·中药成方制剂>是卫生部为解决中药材品种混乱问题,保证人民用药安全有效,颁布的具有权威性的法定标准.据统计,其1～20册共收载成方制剂4052个品种,其中含反药配伍的成方制剂65个,包括含"十八反"药对的品种43个,含"十九畏"药对的品种25个,既含"十八反"又含"十九畏"药对的品种3个.经分析可知,该标准含反药药对的成方中以乌头类与半夏、官桂与赤石脂配伍使用为多;其临床应用特点,含"十八反"药对的成方主要用于风湿痹病、跌打损伤,剂型以丸剂、膏药、橡胶膏剂为主,口服与外用比例相当;含"十九畏"药对的成方主要用于月经不调,以丸剂口服为主.在处方药味数方面,含反药药对的成方以16～30味的处方较多.     

均匀棒纯纵向运动初值问题混合有限元方法的H(div)模误差估计

笔者继续考虑均匀棒纯纵向运动初值问题的混合有限元方法[1],利用广义混合椭圆投影的误差估计,给出了H(div)模最优误差估计,使得该问题得到进一步的解决.     

甘南州草地生态系统现状及可持续发展对策

甘南藏族自治州是甘肃省重点牧区,也是黄河、长江两大水系源区。天然草地面积272.3万hm2,但是,不合理地开发和利用,导致草地生态系统日趋恶化,生产能力下降,严重制约地区经济发展和农牧民脱贫致富。研究如何完善生产经营状况,维持草地生态系统是甘南牧区面临的主要问题。以草定畜,综合治理,科学合理利用是改善草地生态系统和畜牧业可持续发展的唯一途径。     

铁氧化物/沸石对亚甲基蓝和铜离子的吸附

OCZ对Cu2+的吸附.     

CaS:Bi~(3+),Eu~(2+)磷光全的微波快速合成及其荧光特性

在微波场作用下 ,首次快速合成了CaS :Bi3 + Eu2 + 红色磷光体 系统考察了Bi3 + 、Eu2 + 双掺时各种掺杂浓度对磷光体的晶粒尺寸、形貌及发光性质的影响 ,发现Bi3 + 与Eu2 + 离子之间存在着能量传递作用 ,Bi3 + 对CaS :Eu2 + 发光有显然的敏化和增强作用     

永济市小麦-玉米"两晚"栽培技术

文章对影响永济市小麦、玉米的产量进行分析,并提出本市小麦-玉米的"两晚"栽培技术,在不增加投资的情况下,可提高粮食产量,增加农民收入.     

Investigation of hrDNA targeting vector-mediated tumor-specific suicide gene therapy for hepatocellular carcinoma

Vectors pose most pivotal problem of gene therapy[1]. Because of the high transfection efficiency both in vitro and in vivo, the viral vector has been employed in 70% clinical trials of gene therapy (http://www.wiley.co.uk/ genmed/clinical). However, thei…