Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.     

Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis

VEGF-driven tumor angiogenesis has been validated as a central target in several tumor types deserving of continuous and further considerations to improve the efficacy and selectivity of the current therapeutic paradigms. Epsins, a family of endocytic clathrin adaptors, have been implicated in regulating endothelial cell VEGFR2 signaling, where its inactivation leads to nonproductive leaky neo-angiogenesis and, therefore, impedes tumor development and progression. Targeting endothelial epsins is of special significance due to its lack of affecting other angiogenic-signaling pathways or disrupting normal quiescent vessels, suggesting a selective modulation of tumor angiogenesis. This review highlights seminal findings on the critical role of endothelial epsins in tumor angiogenesis and their underlying molecular events, as well as strategies to prohibit the normal function of endogenous endothelial epsins that capitalize on these newly understood mechanisms.     

Some results on covers of complete graphs

In the present note, (n, r, c)-covers withn = (2r−1)c and bipartite double covers of complete graphs are classified.     

在多匹配病例-对照研究中优比的小样本研究

Ｍｅｈｔａ等多（１９８５）指出了建立在计数统计基础上的多匹配病全－对照研究中优化的精确检验的重要性。这里提出了两种新的基于估计和似然比的精确检验法,对这三种精确检验法进行了比较,并把它们与渐近检验作了比较,说明了在样本设计的双国检验中基于似然比的精确检验具有优越性。     

在多匹配病例—对照研究中优比的小样本研究(英文)

Ｍｅｈｔａ等人（１９８５）指出了建立在计数统计基础上的多匹配病例—对照研究中优比的精确检验的重要性．这里提出了两种新的基于估计和似然比的精确检验法,对这三种精确检验法进行了比较,并把它们与渐近检验作比较,说明了在小样本设计的双边检验中基于似然比的精确检验具有优越性．