全文获取类型
收费全文 | 462篇 |
免费 | 2篇 |
专业分类
系统科学 | 9篇 |
教育与普及 | 2篇 |
理论与方法论 | 3篇 |
现状及发展 | 40篇 |
研究方法 | 96篇 |
综合类 | 288篇 |
自然研究 | 26篇 |
出版年
2023年 | 1篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 1篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 6篇 |
2013年 | 6篇 |
2012年 | 56篇 |
2011年 | 78篇 |
2010年 | 13篇 |
2009年 | 4篇 |
2008年 | 53篇 |
2007年 | 43篇 |
2006年 | 42篇 |
2005年 | 32篇 |
2004年 | 38篇 |
2003年 | 23篇 |
2002年 | 29篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1992年 | 1篇 |
1983年 | 1篇 |
1974年 | 2篇 |
1971年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有464条查询结果,搜索用时 15 毫秒
101.
The goal of this paper is to provide an interpretation of Feyerabend's metaphysics of science as found in late works like Conquest of Abundance and Tyranny of Science. Feyerabend's late metaphysics consists of an attempt to criticize and provide a systematic alternative to traditional scientific realism, a package of views he sometimes referred to as “scientific materialism.” Scientific materialism is objectionable not only on metaphysical grounds, nor because it provides a poor ground for understanding science, but because it implies problematic claims about the epistemic and cultural authority of science, claims incompatible with situating science properly in democratic societies. I show how Feyerabend's metaphysical view, which I call “the abundant world” or “abundant realism,” constitute a sophisticated and challenging form of ontological pluralism that makes interesting connections with contemporary philosophy of science and issues of the political and policy role of science in a democratic society. 相似文献
102.
103.
104.
Saal LH Gruvberger-Saal SK Persson C Lövgren K Jumppanen M Staaf J Jönsson G Pires MM Maurer M Holm K Koujak S Subramaniyam S Vallon-Christersson J Olsson H Su T Memeo L Ludwig T Ethier SP Krogh M Szabolcs M Murty VV Isola J Hibshoosh H Parsons R Borg A 《Nature genetics》2008,40(1):102-107
Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype; however, the precise molecular lesions and oncogenic consequences of BRCA1 dysfunction are poorly understood. Here we show that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic and BRCA1-associated hereditary breast cancers. In addition, we identify frequent gross PTEN mutations, involving intragenic chromosome breaks, inversions, deletions and micro copy number aberrations, specifically in BRCA1-deficient tumors. These data provide an example of a specific and recurrent oncogenic consequence of BRCA1-dependent dysfunction in DNA repair and provide insight into the pathogenesis of BBC with therapeutic implications. These findings also argue that obtaining an accurate census of genes mutated in cancer will require a systematic examination for gross gene rearrangements, particularly in tumors with deficient DSB repair. 相似文献
105.
Based on introducing the concept of the metric induced by a set of vectors, as well as minimizing the maximum amplitude of
residual vibrations in the sense of this metric, an approach for determining the balance correction for flexible shafts is
presented. The advantages of the proposed method are two-fold. Firstly, the approach is available when upper bound constraints
on balance corrections exist, and the resulted balance correction is approximately optimal. Secondly, the balance correction
can be easily calculated by solving a linear programming problem. 相似文献
106.
Finberg KE Heeney MM Campagna DR Aydinok Y Pearson HA Hartman KR Mayo MM Samuel SM Strouse JJ Markianos K Andrews NC Fleming MD 《Nature genetics》2008,40(5):569-571
Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin. These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans. 相似文献
107.
Todd JA Walker NM Cooper JD Smyth DJ Downes K Plagnol V Bailey R Nejentsev S Field SF Payne F Lowe CE Szeszko JS Hafler JP Zeitels L Yang JH Vella A Nutland S Stevens HE Schuilenburg H Coleman G Maisuria M Meadows W Smink LJ Healy B Burren OS Lam AA Ovington NR Allen J Adlem E Leung HT Wallace C Howson JM Guja C Ionescu-Tîrgovişte C;Genetics of Type Diabetes in Finland Simmonds MJ Heward JM Gough SC;Wellcome Trust Case Control Consortium Dunger DB Wicker LS Clayton DG 《Nature genetics》2007,39(7):857-864
The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) 相似文献
108.
Presented herein is an index to approximately 800 authors of vascular plant names of Utah. A standardized abbreviation is presented for each author. These are listed alphabetically. Following each abbreviation is the full name and birth and death dates (where available) of each individual. In some cases the date of publication is given when biographical information is not known. 相似文献
109.
Thirteen species of bats occur in Nebraska, but limited information is available on those inhabiting southwestern parts of the state. We investigated the distribution, abundance, and reproductive activity of bats in 5 counties in extreme southwestern Nebraska (Chase, Hays, Dundy, Hitchcock, and Red Willow). From April 2007 to April 2008, we deployed mist nets on 15 occasions at 8 localities over the Republican River and its tributaries. We captured 100 individuals representing 5 species, including the evening bat ( Nycticeius humeralis ), eastern red bat ( Lasiurus borealis ), hoary bat ( Lasiurus cinereus ), big brown bat ( Eptesicus fuscus ), and silver-haired bat ( Lasionycteris noctivagans ). All species raised young in this region of Nebraska, except L. noctivagans , which was documented only during migration. Lactating females of N. humeralis captured on 15 June and volant young captured on 23 June extend known dates of reproductive activity for this species in the state, and an adult female captured on 30 April represents the earliest seasonal record of this species from Nebraska. Our records of evening bats also extend the known distribution of this species farther west in Nebraska than previously reported. Changes in land use throughout the Great Plains during the last century have altered many habitats, such as gallery forests associated with rivers, and distributions of mammals, including bats, have shifted to reflect those ecological changes. 相似文献
110.
Bass AJ Lawrence MS Brace LE Ramos AH Drier Y Cibulskis K Sougnez C Voet D Saksena G Sivachenko A Jing R Parkin M Pugh T Verhaak RG Stransky N Boutin AT Barretina J Solit DB Vakiani E Shao W Mishina Y Warmuth M Jimenez J Chiang DY Signoretti S Kaelin WG Spardy N Hahn WC Hoshida Y Ogino S Depinho RA Chin L Garraway LA Fuchs CS Baselga J Tabernero J Gabriel S Lander ES Getz G Meyerson M 《Nature genetics》2011,43(10):964-968
Prior studies have identified recurrent oncogenic mutations in colorectal adenocarcinoma and have surveyed exons of protein-coding genes for mutations in 11 affected individuals. Here we report whole-genome sequencing from nine individuals with colorectal cancer, including primary colorectal tumors and matched adjacent non-tumor tissues, at an average of 30.7× and 31.9× coverage, respectively. We identify an average of 75 somatic rearrangements per tumor, including complex networks of translocations between pairs of chromosomes. Eleven rearrangements encode predicted in-frame fusion proteins, including a fusion of VTI1A and TCF7L2 found in 3 out of 97 colorectal cancers. Although TCF7L2 encodes TCF4, which cooperates with β-catenin in colorectal carcinogenesis, the fusion lacks the TCF4 β-catenin-binding domain. We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. This study shows previously unidentified levels of genomic rearrangements in colorectal carcinoma that can lead to essential gene fusions and other oncogenic events. 相似文献