An integrated view of the chemistry and mineralogy of martian soils

The mineralogical and elemental compositions of the martian soil are indicators of chemical and physical weathering processes. Using data from the Mars Exploration Rovers, we show that bright dust deposits on opposite sides of the planet are part of a global unit and not dominated by the composition of local rocks. Dark soil deposits at both sites have similar basaltic mineralogies, and could reflect either a global component or the general similarity in the compositions of the rocks from which they were derived. Increased levels of bromine are consistent with mobilization of soluble salts by thin films of liquid water, but the presence of olivine in analysed soil samples indicates that the extent of aqueous alteration of soils has been limited. Nickel abundances are enhanced at the immediate surface and indicate that the upper few millimetres of soil could contain up to one per cent meteoritic material.     

Bitterbrush ( Purshia tridentata Pursh) growth in relation to browsing

The objectives of this study were to compare vegetative and reproductive growth characters of bitterbrush ( Purshia tridentata Pursh) stands as they relate to browsing levels. Growth characters were measured on 10 ecologically diverse stands in southwestern Montana on which browsing ranged from 0% to 60% of all current annual long shoot (LS) growth. Bitterbrush plants exhibited both twig-level and plant-level responses to browsing. Total bud density per plant was similar for browsed and unbrowsed sites, but differed ( P P P P P < 0.05). Our data suggest that long-term unbrowsed plants should not be used as a standard for comparison with normally browsed plants.     

High-energy colliders and the rise of the standard model

Over the past quarter of a century, experiments at high-energy particle colliders have established the standard model as the precise theory of particle interactions up to the 100 GeV scale. A series of important experimental discoveries and measurements have filled in most of the missing pieces and tested the predictions of the standard model with great precision.     

Philosophical Differences: The Case of Architects' Reluctance to Use Strategic Planning Software

A briefing workshop was run in an effort to involve its participants in choosing a strategic direction, and eventual form, for a proposed facility. The workshop was an action research, participative process that sought to improve final design by preconsultation with some relevant stakeholders. This paper will specifically focus on our attempt to use strategic planning software at an early stage of such a workshop. It discusses and illustrates the difficulties of importing a new technique into an established, professional setting where activities and roles may be expressed, or assumed, on the basis of previous experience. More exactly, although we hoped to use our software to analyze and explore participants' design styles, and so predict their likely choice of design option, the architects present undermined such analyzes by playing a role rather than telling the software what they really thought about the various strategic choices. Hence it was, in some ways, a waste of time using our software. We speculate below whether such undermining might be symptomatic of deep philosophical differences between the workshop organizers, planners, and architects. We also examine whether such differences bode ill for the future of architecture.     

Genome-wide association study identifies susceptibility loci for IgA nephropathy

We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance (P values for association between 1.59 × 10?2? and 4.84 × 10?? and minor allele odds ratios of 0.63-0.80). These five loci explain 4-7% of the disease variance and up to a tenfold variation in interindividual risk. Many of the alleles that protect against IgA nephropathy impart increased risk for other autoimmune or infectious diseases, and IgA nephropathy risk allele frequencies closely parallel the variation in disease prevalence among Asian, European and African populations, suggesting complex selective pressures.     

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

The extracellular deposition of misfolded proteins is a characteristic of many debilitating age-related disorders. However, little is known about the specific mechanisms that act to suppress this process in vivo. Clusterin (CLU) is an extracellular chaperone that forms stable and soluble complexes with misfolded client proteins. Here we explore the fate of complexes formed between CLU and misfolded proteins both in vitro and in a living organism. We show that proteins injected into rats are cleared more rapidly from circulation when complexed with CLU as a result of their more efficient localization to the liver and that this clearance is delayed by pre-injection with the scavenger receptor inhibitor fucoidan. The CLU–client complexes were found to bind preferentially, in a fucoidan-inhibitable manner, to human peripheral blood monocytes and isolated rat hepatocytes and in the latter cell type were internalized and targeted to lysosomes for degradation. The data suggest, therefore, that CLU plays a key role in an extracellular proteostasis system that recognizes, keeps soluble, and then rapidly mediates the disposal of misfolded proteins.     

Variation in bitterbrush ( Purshia tridentata Pursh) crude protein in southwestern Montana

The objective of this study was to determine if crude protein varies significantly during late summer and midwinter among stands of bitterbrush ( Purshia tridentata Pursh) in southwestern Montana. A secondary objective was to determine if leaves, when present, contribute significant additional protein in the region. Nine sites with different environmental conditions within a radius of 14.5 km were studied. Bitterbrush leaves and leaders collected in August 1990 and 1991 and February 1991 were used for crude protein and leaf-to-leader ratio determinations. Crude protein differed ( P < 0.001) among sites for both leaves and leaders on individual collection dates. Crude protein in leaves was nearly twice the level found in leaders. Because few leaves were present in February, they increased crude protein in total foliage by only 0.3% over twigs alone. February crude protein levels averaged 6.8% for total foliage, which is below the estimated requirement for wintering deer.