磁性表面手性分子印迹聚合物对氧氟沙星手性分离的研究

研究了一种可快速拆分氧氟沙星的方法;该方法采用分子印迹技术,用二氧化硅包裹的Fe3O4磁性纳米颗粒为载体,再用手性试剂N-正辛基-D-葡萄糖胺作为单体,以氧氟沙星作为模板分子制备磁性表面分子印迹聚合物。该手性聚合物可与右旋氧氟沙星结合,最终分离出左旋氧氟沙星。最后利用外加磁场及透射电子显微镜对于所制备的氧氟沙星磁性分子印迹聚合物的性状进行检测;并对分离得到的左旋氧氟沙星进行旋光度的检测。     

热聚合制备左旋氧氟沙星分子印迹聚合物的条件

以左旋氧氟沙星（LVFX）为模板，以α-甲基丙烯酸（MAA）为功能单体，乙二醇二甲基丙烯酸酯（EDMA）为交联剂，采用热聚合方式，通过条件优化获得了对左氧氟沙星有特异选择性吸附的分子印迹聚合物（MIPs）。最优化务件为n（LVFX）：n（MAA）：n（EDMA）；1：4：15，聚合温度60℃，聚合时间48 h，溶剂氯仿，用量10mL。通过结合实验分析，在最优化备件下制得的MIPs对左氧氟沙星具有很好选择性和吸附能力，分离因子α（LVFX／OLFX）为1．56。     

以Cu2+-邻菲啰啉配合物为模板制备铜离子印迹聚合物

采用分子印迹技术,物质的量比为1∶2的Cu2+-邻菲啰啉配合物为模板,4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,模板、功能单体与交联剂的物质的量比为1∶2∶30,在甲醇中用沉淀聚合法制备了一个铜离子印迹聚合物.该印迹聚合物在室温和pH 5.0的条件下对Cu2+的吸附可以在1h内达到平衡,理论饱和吸附容量(Qmax)为75.01mg/g,印迹因子(IF)为1.77.用该印迹聚合物制备的固相萃取柱对质量浓度为5.0μg/mL的Cu2+的萃取回收率为89.7%,相对标准偏差为4.7%(n=5).表明其有作为分析测定Cu2+时的固相萃取剂的应用前景.     

水杨酸分子印迹聚合物整体柱合成及其固相微萃取应用

以水杨酸为模板分子,4-乙烯吡啶为功能单体,在模板分子∶功能单体∶交联剂为1∶4∶18的条件下,运用原位聚合法在移液枪头中合成了水杨酸印迹聚合物整体柱,并应用于水杨酸的固相微萃取.优化了上样溶液体积、pH、洗脱剂种类、体积、萃取流速等萃取条件,建立了固相微萃取-高效液相色谱定量分析方法.实验结果显示,检出限(LOD)为1.2 ng/mL,回收率的范围92.1%～105.8%,日内、日间精密度(RSD)均小于9.8%.该方法简单快速、选择性好、灵敏度高,适合于环境水样中水杨酸的分离分析.     

氧氟沙星分子印迹聚合物制备条件对比研究

以氧氟沙星为模板分子,2-乙烯基吡啶为功能单体,EDMA为交联剂,AIBN为引发剂,在甲醇水强极性溶剂中,制备了一系列氧氟沙星的分子印迹聚合物.模板分子与功能单体的比例为1∶3～1∶4,功能单体与交联剂的比例为1∶5～1∶6,溶剂种类为非质子化溶剂,60℃以上热引发方式,反应时间在24～36h,实验效果最好.     

复合功能单体法合成氧氟沙星分子印迹材料

以氧氟沙星为模板分子,甲基丙烯酸和2-乙烯基吡啶为复合功能单体,二甲基丙烯酸乙二醇酯为交联剂合成了复合功能单体的印迹聚合物材料.通过静态吸附实验和Scatchard模型分析研究印迹材料对模板分子的吸附容量、特异性和选择性.结果表明:与单一功能单体制备的MIP材料相比,复合单体MIP材料对模板分子及其类似物都存在着较高的吸附容量和更好的选择性.而Scatchard模型证明在MIP复合印迹材料表面存在两种结合方式:一种是呈高选择性亲和力,另一种为弱选择性亲和力.其相应的最大吸附容量分别为48,240μmol/g,在含有20μg/mL氧氟沙星溶液时,复合单体的印迹材料与对应的非印迹材料相比,印迹因子可达到3.20.随后将该材料作为特异性吸附剂结合高效液相色谱对牛奶中痕量的氟喹诺酮进行吸附和检测,取得了理想的重现性(RSD 5.0%)和加标回收率(93.72%～102.14%).     

双酚A分子印迹聚合物的制备及其在环境监测中的应用初探

采用分子印迹技术,以双酚A为模板分子、2-乙烯吡啶为功能单体,通过微球法合成了对双酚A具有高度选择性的分子印迹聚合物(MIPs),以此印迹聚合物为固相萃取填料,试验了聚合物在结构相似底物竞争环境下对双酚A的特异选择性能.通过Scatchard分析,该聚合物对双酚A存在两类不同的结合位点,其中特异性结合的平衡常数达1.78×105 L/mol,表观最大吸附量为7.23μmol/g.固相萃取结果表明:合成的MIPs对双酚A具有高度的特异选择性,为从复杂环境介质中分离富集双酚A提供了一种快速有效的方法.     

2,4-二氯苯氧乙酸磁性印迹聚合物的制备与吸附性能

以2,4-二氯苯氧乙酸(2,4-D)为模板分子,甲基丙烯酸(MAA)为功能单体,Fe3O4为磁性载体,采用乳液聚合方法制备了相应的磁性分子印迹聚合物(Mag-MIPs)。采用透射电镜(TEM)、热重分析(TG)等对Mag-MIPs进行了一系列表征。吸附实验表明该磁性印迹聚合物对2,4-D的吸附能力明显强于非印迹聚合物。采用Mag-MIPs为固相萃取材料,结合高效液相色谱分析,对质量浓度约为50μg·L-1模拟水样中的2,4-D进行了分析检测,样品回收率范围为91.7%~110.4%,相对平均偏差为7.38%(n=3)。     

分子印迹水凝胶固相萃取石油有机硫组分

以壳聚糖为功能单体，制备苯并噻吩类硫组分分子印迹固相萃取剂，系统地研究了其分子识别机理．根据目标分子的结构理性地选择了交联剂、致孔剂和聚合方法，探索了不同制备条件对模板聚合物特异性识别能力的影响；总结了影响印迹聚合物识别能力的一般规律，试验结果显示，以环氧氧丙烷为交联剂制备得到的印迹材料对二苯并噻吩的吸附容量达到17．53 mg／g。     

对氯苯酚分子印迹复合膜的制备及其表征

分子印迹聚合物(MIP)制备的目标是获得在空间和结合位点上与某一分子(模板分子或印迹分子)完全匹配的聚合物.因其具有构效预定性、特异识别性和广泛实用性三大特点而发展迅速.分子印迹复合膜是在现有膜的基础上,在其表面或膜孔中制备一层分子印迹聚合物,使其既有MIP的特点,又有膜的稳定性.以对氯苯酚为模板分子,偏氟膜为支撑膜,丙烯酰胺或甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,采用热引发原位聚合方法制备了对氯苯酚分子印迹聚合物膜.通过FTIR与扫描电子显微镜对膜进行进行了表征,研究了分子印迹膜对对氯苯酚及其结构类似物(2-氯苯酚、苯酚)的静态吸附量.结果表明:印迹复合膜对模板分子对氯苯酚的吸附量约为非印迹膜的3倍;且对模板分子对氯苯酚及异构体2-氯苯酚的吸附量远远大于苯酚,可能是复合膜上印迹聚合物的孔穴要比苯酚尺寸大的原因.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

海南岛地体及其毗邻陆缘晚中生代—新生代古地磁研究和构造演化

本文叙述了对海南岛及其毗邻大陆边缘白垩纪到第四纪地层岩石进行古地磁研究的全部工作过程。通过分析岩石中剩余磁矢量的磁偏角及磁倾角的变化,提出海南岛白垩纪以来经历的构造演化模式如下:早期伴随顺时针旋转而向南迁移,后期伴随逆时针转动并向北运移。联系该地区及邻区的地质、地球物理资料,对海南岛上述的构造地体运动提出以下认识:北部湾内早期有一拉张作用,主要是该作用使湾内地壳显著伸长减薄,形成北部湾盆地。从而导致了海南岛的早期构造运动,而海南岛后期的构造运动则主要是受南海海底扩张的影响。海南地体运动规律的阐明对于了解北部湾油气盆地的形成演化有重要的理论和实际意义。     

Exciton Seebeck in Molecular Systems

Various applications relevant to the exciton dynamics,such as the organic solar cell,the large-area organic light-emitting diodes and the thermoelectricity,are operating under temperature gradient.The potential abnormal behavior of the exicton dynamics driven by the temperature difference may affect the efficiency and performance of the corresponding devices.In the above situations,the exciton dynamics under temperature difference is mixed with     

Achieving Unusual States of Matter Under High Pressure

The elongation method,originally proposed by Imamura was further developed for many years in our group.As a method towards O(N)with high efficiency and high accuracy for any dimensional systems.This treatment designed for one-dimensional(ID)polymers is now available for three-dimensional(3D)systems,but geometry optimization is now possible only for 1D-systems.As an approach toward post-Hartree-Fock,it was also extended to     

《Chinese Science Bulletin》SUBJECT INDEX TO VOLUME 59(2014)

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An on-line scaling method for improving scalability of a database cluster

The explosive growth of the Internet and database applications has driven database to be more scalable and available, and able to support on-line scaling without interrupting service. To support more client's queries without downtime and degrading the response time, more nodes have to be scaled up while the database is running. This paper presents the overview of scalable and available database that satisfies the above characteristics. And we propose a novel on-line scaling method. Our method improves the existing on-line scaling method for fast response time and higher throughputs. Our proposed method reduces unnecessary network use, i.e. , we decrease the number of data copy by reusing the backup data. Also, our on-line scaling operation can be processed parallel by selecting adequate nodes as new node. Our performance study shows that our method results in significant reduction in data copy time.     

An improved R-tree based on childnode''s probability

R-Tree is a good structure for spatial searching. But in this indexing structure,either the sequence of nodes in the same level or sequence of traveling these nodes when queries are made is random. Since the possibility that the object appears in different MBR which have the same parents node is different, if we make the subnode who has the most possibility be traveled first, the time cost will be decreased in most of the cases. In some case, the possibility of a point belong to a rectangle will shows direct proportion with the size of the rectangle. But this conclusion is based on an assumption that the objects are symmetrically distributing in the area and this assumption is not always coming into existence. Now we found a more direct parameter to scale the possibility and made a little change on the structure of R-tree, to increase the possibility of founding the satisfying answer in the front sub trees. We names this structure probability based arranged R-tree (PBAR-tree).     

Integrating GIS Web services based on mediating architecture

The geographic information service is enabled by the advancements in general Web service technology and the focused efforts of the OGC in defining XML-based Web GIS service. Based on these models, this paper addresses the issue of services chaining,the process of combining or pipelining results from several interoperable GIS Web Services to create a customized solution. This paper presents a mediated chaining architecture in which a specific service takes responsibility for performing the process that describes a service chain. We designed the Spatial Information Process Language (SIPL) for dynamic modeling and describing the service chain, also a prototype of the Spatial Information Process Execution Engine (SIPEE) is implemented for executing processes written in SIPL. Discussion of measures to improve the functionality and performance of such system will be included.     

Tracking data management using topology of moving object database system for moving object constrained trajectory in LBS application

Advances in wireless technologies and positioning technologies and spread of wireless devices, an interest in LBS (Location Based Service) is arising. To provide location based service, tracking data should have been stored in moving object database management system (called MODBMS) with proper policies and managed efficiently. So the methods which acquire the location information at regular time intervals then, store and manage have been studied. In this paper, we suggest tracking data management techniques using topology that is corresponding to the moving path of moving object. In our techniques, we update the MODBMS when moving object arrived at a street intersection or a curved road which is represented as the node in topology and predict the location at past and future with attribute of topology and linear function. In this technique, location data that are corresponding to the node in topology are stored, thus reduce the number of update and amount of data. Also in case predicting the location,because topology are used as well as existing location information, accuracy for prediction is increased than applying linear function or spline function.