口服降糖药物的临床应用

为指导临床正确用药，对五类降糖药从作用机制、副作用、适应证等方面作了总结，目的在于引起临床医生注意，提高Ⅱ型糖尿病疗效。     

糖尿病人口服降糖药物的合理应用

糖尿病是一种比较常见的具有遗传倾向的内分泌代谢疾病，是由于胰岛素绝对或相对不足引起人体精、脂肪、蛋白质代谢紊乱的一种慢性病变，如不及时控制病情发展，可相继出现心血管系统，神经系统，泌尿系统的严重并发症。临床上，大部分病人在饮食疗法的基础上，同时应用口服降糖药物来控制血糖，以减轻胰岛负担。因此，合理地应用Q服降糖药物是治疗糖尿病的主要手段。目前，临床常用的口服降糖药物主要有磺膨类和双肌类两种。1、横田类降据药物l、l作用原理磺照类药物能刺激胰岛B细胞分泌胰岛素。用药后血内胰岛素增多，胰岛内含量减少，反…     

具有降糖作用的中草药及降糖机理

糖尿病是一种常见的内分泌代谢紊乱性疾病,糖尿病及其并发症是威胁人类健康的主要疾病之一,死亡率仅次于肿瘤和心血管疾病,在各种疾病中居第三位。中医治疗糖尿病历史久远,而中草药降血糖作用温和持久,毒副作用小,传统中草药治疗糖尿病的作用机理常为多靶点、多效应、多功能的综合作用,越来越受到重视,深入挖掘中草药治疗糖尿病已成为新药开发的热点。     

KS降糖作用及机理研究

试验观察了KS对Alloxan和Streptozotocin等所致家兔、大鼠、小鼠糖尿病模型及非基因遗传性NIDDM模型的降糖作用，并在体外观察了其对α－淀粉酶和α－葡萄糖苷酶活性的影响，结果表明：１）KSHT在９０、１２０、１２０mg?kg时对家兔、大鼠、小鼠Alloxan糖尿病模型有极显著的降血糖作用，最大降糖率分别为３８．２２％、３１．７４％、４２．３６％。２）KSHT在１２０、１２０mg?kg对大鼠、小鼠Streptozotocin糖尿病模型有显著的降血糖作用，最大降糖率分别为４２．３６％、４３．２７％。３）对非基因遗传性NIDDM模型动物有降血糖…     

北大医学专家揭示二甲双胍降糖作用新机制

北京大学医学部生理与病理生理学系的徐国恒和北京大学第一医院（北大医院）内分泌科郭晓慧教授，阐明了二甲双胍抑制脂肪分解的效应是该药降低糖尿病患者血浆游离脂肪酸水平的细胞生物学基础，也表明脂肪组织是二甲双胍作用的新靶点，有助于加深对二甲双胍类降糖药物药理机制的理解。据悉，研究论文已发表在8月份出版的最新一期国际学术期刊《分子内分泌学杂志》上。     

胰岛素泵强化降糖治疗糖尿病患者32例护理体会

目的：探讨护理干预法对使用胰岛素泵的糖尿病患者的降糖效果方面的影响。方法：对32例胰岛素泵使用者给予心理、技术等全方位护理。结果：证实32例患者均在短时间内得到较好的血糖控制，且较少有低血糖出现，生活质量亦得到一定程度的提高。结论：对胰岛素泵保障置使用者给予全方位护理及指导为顺利治疗提供了基础，有助于提高治疗效果。     

药食两用降糖中草药

本文对卫生部公布的药食两用中草药中具有降糖功效的几种中草药的药理作用进行了综述。     

降糖甲片的药效学实验

目的　观察降糖甲片对高血糖大、小鼠的降血糖作用。方法　用四氧嘧啶致大、小鼠高血糖模型 ,观察给予降糖甲片后血糖值变化情况。结果　降糖甲片有一定的降血糖作用     

香蕉花蕊中生物碱对糖尿病小鼠的降糖作用

本文主要研究香蕉花蕊中生物碱对糖尿病小鼠的降糖作用。香蕉花蕊经粉碎、醇提、酸水提、碱化后再用氯仿提取得到生物碱。将上面得到的生物碱分三个不同浓度灌胃喂养四氧嘧啶糖尿病造模小鼠后测定其第3、7、12天空腹血糖的变化情况，结果显示生物碱浓度越大，其降糖效果越好。     

滋肾蓉精降糖胶囊治疗Ⅱ型糖尿病近期疗效观察

我们自１９９６年１月～１９９７年９月，运用滋肾蓉精降糖胶囊治疗Ⅱ型糖尿病１４８例，近期疗效满意，报告如下。１临床资料在我院糖尿病专科就诊的２７２例Ⅱ糖尿病均符合（ＷＨＯ）关于糖尿病诊断标准。随机分成两组，观察组１４８例，其中男８９例，女５９例，年龄最...     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

橡胶颗粒沥青混合料低温抗裂性试验研究

以AC-13级配为基础,将橡胶颗粒代替部分集料掺入混合料中,以低温弯曲试验为评价方法对不同橡胶颗粒掺量下沥青混合料的低温抗裂性进行研究,并引入应变能密度值对混合料的低温抗裂性进行综合评价.试验结果表明:橡胶颗粒沥青混合料试件的破坏微应变均超过2 300,满足冬寒区的技术指标;无论是否掺加橡胶颗粒,随着温度的下降,沥青混合料破坏时的最大弯拉强度增大,弯拉应变降低,劲度模量增大;弯曲应变能密度在胶粒掺量为1%左右时具有较大的弯曲应变能密度值,此时橡胶颗粒沥青混合料具有较好的低温抗裂性.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.