肝干细胞及其在肝再生医学中的应用

成体干细胞具有多向分化的潜能,在适宜的环境中,它们可以跨系、甚至跨胚层分化,这种现象称为"可塑性"(plasticity).多种成体组织来源的干细胞可在受者(包括小鼠、大鼠和人)肝脏内分化为肝细胞和胆管上皮细胞,为成体干细胞移植治疗终末期肝病提供了新思路.文中就不同来源的肝干细胞是否可以向肝细胞分化、影响干细胞分化的因素和调控机制以及干细胞在肝再生医学中的应用等方面做一综述.     

脑动静脉畸形的血管内栓塞治疗

目的 :探讨脑动静脉畸形 (AVM)血管内栓塞治疗的疗效。方法 :2 0例脑AVM患者 ,行数字减影全脑血管造影 (DSA)后 ,采用Magic - 1 8F ,1,5F或MP 1 2F微导管系与α -氰基丙烯酸正丁酯 (NBCA)栓塞剂 ,进行血管内栓塞治疗 ,其中 6例栓塞后行γ -刀治疗。结果 :全部病人手术过程顺利 ,疗效满意。栓塞达 70 %以上 8例 ,70 %以下 12例。 1例发生短暂的血管痉挛 ,无出血等并发症和死亡发生。术后随访 ,全组临床症状均明显改善。结论 :血管内栓塞治疗脑AVM可提高治愈率 ,降低并发症和病死率 ,是一种安全而有效的治疗手段     

血管内栓塞治疗颅内动脉瘤破裂37例

目的:探讨颅内动脉瘤破裂血管内栓塞治疗的效果及技术要点。方法:对37例破裂的颅内动脉瘤,经血管内途径,采用单纯的可脱性弹簧圈(GDC/EDC)或血管内支架结合可脱性弹簧圈技术进行瘤内栓塞。结果:37例均获成功栓塞,其中动脉瘤完全填塞28例,填塞90%以上9例,无神经系统并发症。一年后复查未见复发。结论:破裂颅内动脉瘤的血管内栓塞是一种安全有效的治疗手段。     

骨髓干细胞与急性心肌梗死的血管新生

骨髓干细胞可分化为心肌细胞、血管内皮细胞、平滑肌细胞等，能再生心肌和血管，可用于心肌梗死的治疗。本文就骨髓干细胞在血管新生方面的生物学特性及其对心梗后的血管新生作用作一综述。     

微弹簧圈血管内栓塞治疗48例颅内囊状动脉瘤

目的：介绍微弹簧圈血管内栓塞治疗48例颅内囊状动脉瘤．方法：所有病例均经股动脉穿刺插管选择性全脑血管造影确诊,在数字减影血管造影监视下行可脱性弹簧躅血管内栓塞治疗．结果：本组48例中无死亡病例,完全栓塞39例,不完全栓塞8例,未行治疗1例．结论：微弹簧圈血管内栓塞治疗颅内动脉瘤是可行的治疗方法．其效果确实,创伤小,病人恢复快．     

干细胞修复与再生

近些年来，干细胞凭借其高度的发育可塑性，引起了医学与生物学界的极大兴趣。也许在不久的将来，我们人类体内所有受损或功能退化的组织都可以通过干细胞移植来进行修复与替换。从20世纪70年代初开始的骨髓造血干细胞移植已经让无数恶性血液病患者的生命得以延续，但最接近全能性的胚胎干细胞的研究尚存在着伦理学和成瘤性等问题，其它成体干细胞的研究也还处于起步阶段，在真正应用到f临床治疗前还需要进行大量的基础研究与临床前实验。     

我校附属协和医院糖尿病足治疗研究取得重大突破

日前，由我校协和医院血管外科金毕教授等施行的自体骨髓干细胞移植治疗下肢缺血取得了重大进展．     

加拿大科学家用干细胞在实验鼠体内生成血管

他们是利用人体骨髓干细胞在实验鼠身上生成新血管。这项成果有望应用于治疗人类外周动脉等疾病。论文发表在美国《血液》杂志上。研究人员从人体骨髓中提取干细胞,并从中分离出3种不同类型的促血管生成干细胞,将处理过的于细胞注射到实验鼠循环系统中。     

加拿大科学家用干细胞在实验鼠体内生成血管

<正>他们是利用人体骨髓干细胞在实验鼠身上生成新血管。这项成果有望应用于治疗人类外周动脉等疾病。论文发表在美国《血液》杂志上。研究人员从人体骨髓中提取干细胞,并从中分离出3种不同类型的"促血管生成干细胞",将处理过的干细胞注射到实验鼠循环系统中。研究人员事先已将这些实验鼠腿部的一动     

科技大观

美科学家用人体胚胎干细胞培育出血管 美国麻省理工学院的科学家近日宣布,他们首次利用人体胚胎干细胞培育出毛细血管,进一步证明了胚胎干细胞技术在治疗心血管疾病等领域的应用潜力。 干细胞是指能分化成各种组织的原始细胞。从人体胚眙中提取的胚胎干细胞分化能力尤其强     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

橡胶颗粒沥青混合料低温抗裂性试验研究

以AC-13级配为基础,将橡胶颗粒代替部分集料掺入混合料中,以低温弯曲试验为评价方法对不同橡胶颗粒掺量下沥青混合料的低温抗裂性进行研究,并引入应变能密度值对混合料的低温抗裂性进行综合评价.试验结果表明:橡胶颗粒沥青混合料试件的破坏微应变均超过2 300,满足冬寒区的技术指标;无论是否掺加橡胶颗粒,随着温度的下降,沥青混合料破坏时的最大弯拉强度增大,弯拉应变降低,劲度模量增大;弯曲应变能密度在胶粒掺量为1%左右时具有较大的弯曲应变能密度值,此时橡胶颗粒沥青混合料具有较好的低温抗裂性.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

Quantitative trait loci （QTLs） for quality traits related to protein and starch in wheat

Quality traits in wheat （Triticum aestirum L.） were studied by quantitative trait locus （QTL） analysis in a recombinant inbred line （RIL） population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross （ChSh）. Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99-40.52% of phenotypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1 D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster including protein and starch traits on chromosome 1D.     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.