How to express tumours using membrane systems

In this paper we discuss the potential usefulness of membrane systems as tools for modelling tumours. The approach is followed both from a macroscopic and a microscopic point of view. In the first case, one considers the tumour as a growing mass of cells, focusing on its external shape. In the second case, one descends to the microscopic level, studying molecular signalling pathways that are crucial to determine if a cell is cancerous or not. In each of these approaches we work with appropriate variants of membrane systems.     

Evidence for a charge-shift electrochromic mechanism in a probe of membrane potential.

Extrinsic optical probes have become important tools for monitoring membrane potential, with probes now available for many tissue or cell suspension systems. In each case that has been studied in detail, it seems that the mechanism involves a shift in the equilibrium population of the probe from one chemical environment to another in response to the transmembrane potential; the environments perturb the probe's spectrum differently. As this indirect mechanism involves a redistribution of dye between chemical environments that are likely to vary if a given probe is transferred from one membrane to another, a potential probe that is effective and calibrated for all membrane systems has not been realised. We present here evidence for a direct response of a probe chromophore to the electric field across membrane systems. The results suggest it might be possible to develop a universal set of membrane probes.     

有效微观状态数与系综变换

首先提出有效微观状态数的概念，以及为出发点阐明尽管主其本质看他们都与孤立系的微观状态数的地位相当，证明了对于不同独立参量的系统，相应的有效微观状态数都扮演了特性函数的角色，于是由独立参量的各种组合会有各种有效微观状态数，从而有各种相应的系综。     

受非线性作用的微观粒子的运动特性及其非线性量子力学理论(Ⅰ)

与线性场的情况相比，微观粒子在非线性作用下的运动特性和本性发生很大变化，这说明在线性作用和非线性场中微观粒子的性质是明显不同的．这启示我们必须建立微观粒子在非线性体系或非线性场中运动规律的新理论．为此研究了与线性量子力学描写的微观量子效应迥然不同的宏观量子效应与非线性作用下的孤立子运动的紧密关系．结合现代孤立子理论和超导与超流理论，首先提出了非线性量子力学的基本原理及在此基础上建立了系统、完整的非线性量子力学理论体系，以及由此理论得出的一些新结论．最后还论证这个理论的正确性和自洽性，理论的运用范围及它的重大意义．     

膜污染与清洗

各种膜分离已在分离过程中成为最新的技术之一。膜体系的发展有很大的前景 ,但膜的污染问题仍是一个难题 ,它限制了膜的广泛应用。文章概述了膜污染的机理、预防措施及其清洗方法。并根据这些原则对微滤啤酒废水引起的膜污染的清洗方法进行了研究 ,通过比较试验 ,选择了恰当的清洗剂和清洗工艺 ,快速恢复了膜通量     

Experimental realization of a one-atom laser in the regime of strong coupling

Conventional lasers (from table-top systems to microscopic devices) typically operate in the so-called weak-coupling regime, involving large numbers of atoms and photons; individual quanta have a negligible impact on the system dynamics. However, this is no longer the case when the system approaches the regime of strong coupling for which the number of atoms and photons can become quite small. Indeed, the lasing properties of a single atom in a resonant cavity have been extensively investigated theoretically. Here we report the experimental realization of a one-atom laser operated in the regime of strong coupling. We exploit recent advances in cavity quantum electrodynamics that allow one atom to be isolated in an optical cavity in a regime for which one photon is sufficient to saturate the atomic transition. The observed characteristics of the atom-cavity system are qualitatively different from those of the familiar many-atom case. Specifically, our measurements of the intracavity photon number versus pump intensity indicate that there is no threshold for lasing, and we infer that the output flux from the cavity mode exceeds that from atomic fluorescence by more than tenfold. Observations of the second-order intensity correlation function demonstrate that our one-atom laser generates manifestly quantum (nonclassical) light, typified by photon anti-bunching and sub-poissonian photon statistics.     

How a membrane agent buys goods in a membrane store

In this paper we consider a specific model of membrane systems, i. e. membrane systems with attributes. In these systems, the information is placed at the membranes in form of attributes, no objects are considered inside the membranes except for other membranes. The membrane system with attributes evolves according to rules that compute new values for the attributes from the attributes assigned to the membranes involved in the rule. The model of membrane systems with attributes allows us to specify business transactions in a precise way and to simulate different models for such transactions with a suitable tool for membrane systems with attributes.     

How a membrane agent buys goods in a membrane store

In this paper we consider a specific model of membrane systems, i. e. membrane systems with attributes. In these systems, the information is placed at the membranes in form of attributes, no objects are considered inside the membranes except for other membranes. The membrane system with attributes evolves according to rules that compute new values for the attributes from the attributes assigned to the membranes involved in the rule. The model of membrane systems with attributes allows us to specify business transactions in a precise way and to simulate different models for such transactions with a suitable tool for membrane systems with attributes.     

Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage

Many observations suggest the presence of transmembrane linkages between the cytoskeleton and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal a co-alignment between actin filaments at the cell surface and extracellular fibronectin. These associations are seen at sites of cell matrix interaction, frequently along stress fibres and sometimes where these bundles of microfilaments terminate at adhesion plaques (focal contacts). Non-morphological evidence also indicates a functional linkage between the cytoskeleton and extracellular matrix. Addition of fibronectin to transformed cells induces flattening of the cells and a reorganization of the actin cytoskeleton, with the concomitant appearance of arrays of stress fibres. Conversely, disruption of the actin cytoskeleton by treatment with cytochalasin B leads to release of fibronectin from the cell surface. As yet, there is no detailed knowledge of the molecules involved in this transmembrane linkage, although several proteins have been suggested as candidates in the chain of attachment between bundles of actin filaments and the cytoplasmic face of the plasma membrane: these include vinculin, alpha-actinin and talin, each one having been identified at regions where bundles of actin filaments interact with the plasma membrane and underlying cell-surface fibronectin. Recently, the cell-substrate attachment (CSAT) antigen has been identified as a plasma membrane receptor for fibronectin, raising the possibility that this glycoprotein complex may serve as a bridge between fibronectin and one or more of the underlying cytoskeletal components mentioned. Here we have investigated the interaction of the purified CSAT antigen with these cytoskeletal components, and we demonstrate an interaction specifically between the CSAT antigen and talin.     

链式膜系统及直接(间接)膜算法与聚类分析研究进展

当前关于膜计算的研究有很多,但是大部分都停留在理论研究层面,关于膜计算的应用研究依然比较少.现有膜系统主要包括细胞型膜系统、组织型膜系统和神经型膜系统.现有膜系统及其变形都是基于图结构的设计,为了进一步扩展膜系统的应用能力,将现有的基本膜系统结合离散Morse理论,创建了新型的单纯形P系统.同时将细胞的多维框架思想加入膜系统研究中,从形式化的角度,创建了膜系统的链式结构.将膜系统的极大并行性和聚类分析模型进行结合,不仅可以用于处理高复杂度、数量庞大的数据集,而且还可以提高聚类算法的性能,具有广泛的应用价值.针对两种新型膜系统进行了详细介绍,同时将膜系统与聚类问题进行结合的研究进行了概述.     

Experimental long-lived entanglement of two macroscopic objects

Entanglement is considered to be one of the most profound features of quantum mechanics. An entangled state of a system consisting of two subsystems cannot be described as a product of the quantum states of the two subsystems. In this sense, the entangled system is considered inseparable and non-local. It is generally believed that entanglement is usually manifest in systems consisting of a small number of microscopic particles. Here we demonstrate experimentally the entanglement of two macroscopic objects, each consisting of a caesium gas sample containing about 1012 atoms. Entanglement is generated via interaction of the samples with a pulse of light, which performs a non-local Bell measurement on the collective spins of the samples. The entangled spin-state can be maintained for 0.5 milliseconds. Besides being of fundamental interest, we expect the robust and long-lived entanglement of material objects demonstrated here to be useful in quantum information processing, including teleportation of quantum states of matter and quantum memory.     

Fluorescence correlation spectroscopy in laser gradient field

Fluorescence correlation spectroscopy (FCS) is capable of probing dynamic processes in living biological systems. From photon fluctuation of fluorescing particles which diffuse through a small detection volume, FCS reveals information on the concentration and the structure of the particles, as well as information on microscopic environment. In this note, we study the radiation forces experienced by Rayleigh particles in a laser field in details, and analyze the effects of gradient field on FCS measurements.     

Statistical mechanics of a gas-fluidized particle

Characterization of the microscopic fluctuations in systems that are far from equilibrium is crucial for understanding the macroscopic response. One approach is to use an 'effective temperature'--such a quantity has been invoked for chaotic fluids, spin glasses, glasses and colloids, as well as non-thermal systems such as flowing granular materials and foams. We therefore ask to what extent the concept of effective temperature is valid. Here we investigate this question experimentally in a simple system consisting of a sphere placed on a fine screen in an upward flow of gas; the sphere rolls because of the turbulence it generates in the gas stream. In contrast to many-particle systems, in which it is difficult to measure and predict fluctuations, our system has no particle-particle interactions and its dynamics can be captured fully by video imaging. Surprisingly, we find that the sphere behaves exactly like a harmonically bound brownian particle. The random driving force and frequency-dependent drag satisfy the fluctuation-dissipation relation, a cornerstone of statistical mechanics. The statistical mechanics of near-equilibrium systems is therefore unexpectedly useful for studying at least some classes of systems that are driven far from equilibrium.     

Compositional asynchronous membrane systems

This paper presents an algorithmic way of building complex membrane systems by coupling elementary membranes. Its application seems particularly valuable in the case of asynchronous membrane systems, since the resulting membrane system remains asynchronous. The composition method is based on a handshake mechanism implemented by using antiport rules and promoters.     

Compositional asynchronous membrane systems

This paper presents an algorithmic way of building complex membrane systems by coupling elementary membranes. Its application seems particularly valuable in the case of asynchronous membrane systems, since the resulting membrane system remains asynchronous. The composition method is based on a handshake mechanism implemented by using antiport rules and promoters.     

Detection of geometric phases in superconducting nanocircuits

When a quantum-mechanical system undergoes an adiabatic cyclic evolution, it acquires a geometrical phase factor' in addition to the dynamical one; this effect has been demonstrated in a variety of microscopic systems. Advances in nanotechnology should enable the laws of quantum dynamics to be tested at the macroscopic level, by providing controllable artificial two-level systems (for example, in quantum dots and superconducting devices). Here we propose an experimental method to detect geometric phases in a superconducting device. The setup is a Josephson junction nanocircuit consisting of a superconducting electron box. We discuss how interferometry based on geometrical phases may be realized, and show how the effect may be applied to the design of gates for quantum computation.     

模拟计算漂移速度线形对弱耦合超晶格纵向输运的影响

结合宏观和微观模型,分别模拟计算有效漂移速度V(f)线形对GaAs AlAs掺杂弱耦合窄垒和宽垒超晶格纵向输运的影响.U-I关系的第一平台的计算结果显示出与超晶格周期数相同的锯齿分支.计算结果还表明宽垒样品U-I关系的第一平台的宽度随流体静压(大于临界压力)的增加而明显变小,而窄垒样品U-I关系的第一平台的宽度则不随流体静压(大于临界压力)的增加而变化.计算结果与实验数据基本吻合.     

常系数线性中立型微分方程周期解存在唯一的充要条件

本文利用Fourier级数讨论具有常系数的任意阶中立型泛函微分方程的周期解，除一种特殊情况外，我们得到了用有限代数方程组描述的周期解存在唯一性的充要条件，对这种特例，我们也得到了若干实用结果．     

Quantum superposition of distinct macroscopic states

In 1935, Schrodinger attempted to demonstrate the limitations of quantum mechanics using a thought experiment in which a cat is put in a quantum superposition of alive and dead states. The idea remained an academic curiosity until the 1980s when it was proposed that, under suitable conditions, a macroscopic object with many microscopic degrees of freedom could behave quantum mechanically, provided that it was sufficiently decoupled from its environment. Although much progress has been made in demonstrating the macroscopic quantum behaviour of various systems such as superconductors, nanoscale magnets, laser-cooled trapped ions, photons in a microwave cavity and C60 molecules, there has been no experimental demonstration of a quantum superposition of truly macroscopically distinct states. Here we present experimental evidence that a superconducting quantum interference device (SQUID) can be put into a superposition of two magnetic-flux states: one corresponding to a few microamperes of current flowing clockwise, the other corresponding to the same amount of current flowing anticlockwise.     

顾及2套坐标误差的三维坐标变换方法

探讨顾及2套坐标误差改正数的三维坐标转换模型,以2套坐标改正数的加权平方和最小为准则导出了转换参数的解算公式;并根据公共点的坐标改正数以及公共点与待转换点间的协方差阵计算待转换点的坐标改正数并对其改正,从而求得近似无缝的坐标转换结果.试验表明:当公共点与转换点坐标相关性较大时,该方法能显著地提高坐标转换精度.