High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

With the support of the National Natural Science Foundation of China and the National Basic Research Program of China, Prof. Wei Wensheng＇s laboratory at the School of Life Sciences, Peking University, published a research article ＂High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells＂ in Nature （ 2014, 509（7501）： 487 491）.     

Evidence of van Hove singularities in ordered grain boundaries of graphene

With the support by the National Natural Science Foundation of China and National Basic Research Program of China, Prof. Hou Jianguo and Prof. Wang Bing＇s laboratory at Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, reported the existence of van Hove singularities in ordered grain boundaries in graphene, which was published in Physical Review Letters （2014, 112： 226802）.     

Hollow-tunneled graphitic carbon nanofibers as high-performance anode materials

With the support by the National Natural Science Foundationof China （Grant No. 51274240）, Prof. Zhou Xiangyang＇s laboratory at the School of Metallurgy and Environment, Central South University, reported an excellent anode material for lithium ion batteries （LIBs）, naming activated N-doped hollow-tun- neled graphitic carbon nanofibers （ANHTGCNs）, which was published in Energy ＆ Environmental Science （2014, 7： 2689-2696）. And the follow up work that focused on a three-dimensional graphene architecture was published in Nano Energy （2014, 8.. 62 70）. These studies were co-authored with Prof. Zhou Limin＇s group from the Hong Kong Polytechnic University.     

A novel inducible receptor on macrophages protects against endotoxin shock

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Wang Hongyan＇s laboratory at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, reported VEGFR-3 as a novel inducible receptor on macrophages to protect against endotoxin shock. This work was published as a cover story in Immunity （2014, 40（4）： 501--14）.     

Direct,nonoxidative conversion of methane to ethylene,aromatics, and hydrogen

With the support by the National Natural Science Foundation of China （（;rant Nos. 21321002, 1107.9005, 21033009 and 21103181） and the Ministry of Science and Technology （the National Basic Research Program of China, （;rant Nos. 2011CBA00503 and 2013CB933100）, Prof. Bao Xinhe＇s team at the State Key I.aboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, developed a new process of direct, nonoxidative conversion of methane to ethylene, aromatics, and hydrogen, which is published in Science （2014, 344：616 619）.     

Characterization of lipid-rich aortic plaques by intravascular photoacoustic tomography

With the support by the National Natural Science Foundation of China （Grant Nos. 61361160414, 61331001 and 81127004） and the National Basic Research Program of China （Grant Nos. 2010CB732602 and 2011CB910402）. Pro{. Xing＇s laboratory at the Ministry of Education Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, reported the characterization of lipid- rich aortic plaques by intravascular photoacoustic tomography. Ex-vivo and in-vivo validation in a rabbit atherosclerosis model with histologic correlation, which was published in Journal of the American College of Cardiology （2014, 64（4）： 385--390）.     

Thymine DNA glycosylase promotes Wnt/β-catenin signaling

With the support by the National Natural Science Foundation of China （Grant Nos. 31230044, 30930052 and 30900763） and the Ministry of Science and Technology of China （Grant No. 2010CB912100）, Prof. Li I.in＇s laboratory at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, reported a novel function of thymine DNA glycosylase （TDG） as a coactivator in Wnt signaling through cooperating with CBP, which was published in Journal of Molecular Cell Biology （2014, 6： 231--239）.     

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Song Erwei＇s laboratory at Sun Yat-Sen Memorial Hospital, Sun Yat Sen University, reported that a positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis, which was published in Cancer Cell （2014, 25（5）： 605 620）.     

Structural TET-mediated insight into 5mC oxidation

With the support by the National Natural Science Foundation of China （Grant Nos. 31270779 and 31030019） and National Basic Research Program of China （ Grant Nos. 2011CB965300 and 2009CB918600）, Prof. Xu Yanhui＇s laboratory at Fudan University Shanghai Cancer Center （FUSCC） and Institute of Biomedical Sciences （IBS）, Fudan University, reported the crystal structure of TET2-DNA complex, which was published in Cell （2013 , 155（7）： 1545 55）.     

A hole-conductor-free,fully printable mesoscopic perovskite solar cell with high stability

With the support by the National Natural Science Foundation of China （Grant No. 61106056）, Prof. Han Hongwei＇s group at Wuhan National I.aboratory for Optoelectronics, Huazhong University of Science and Technology, reported a hole-conductor-free, fully printable mesoscopic perovskite solar cell with high stability, which was published in Science （2014, 345（6194）.. 295--298）.     

Organic batteries operated at -70℃

正With the great support by the National Natural Science Foundation of China,the research team directed by Prof.Xia YongYao(夏永姚)and Prof.Wang YongGang(王永刚)at the Department of Chemistry,Institute of New Energy,iChEM (Collaborative Innovation Center of Chemistry for Energy Materials),Fudan University,recently designed a rechargeable battery that can be operated at the ultra-low     

Genomic and molecular characterization of esophageal squamous cell carcinoma

Supported by the National Natural Science Foundation of China （Grant No. 81330052） and National High-Tech Rg.D Program of China （Grant Nos. 2012AA02A503 and 2012AAO2A209）, Prof. Wang Mingrong＇s group at the Cancer Institute/Hospital, Chinese Academy of Medical Sciences published their recenl study, entitled ＂Genomic and molecular characterization of esophageal squamous cell carcinoma＂ in Nature Genetics （ 2014, 46（5）. 467 473）.     

Nanotwinned diamond with unprecedented hardness and stability

Supported by the National Natural Science Foundation of China （Grant Nos. 51121061. 51172197 and 51332OO5） and the Ministry of Science and Technology of China, Prof. Tian Yongjun＇s Group at the State Key Imhoratory of Metastable Materials Science and Technology, Yanshan University successfully synthesized the nanotwinned diamond （nt-diamond） with unprecedented hardness and stability, which was published in Nature （2014, 510（7504）： 250 -3）.     

Structural analysis and functional exploration of a leukemia-associated protein,IQCG

Supported financially by the National Natural Science Foundation of China, Prof. Chen Saijuan and Chen Zhu＇s laboratory at Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University （SJTU） School of Medicine, published a research article in Nature Communications （2014, 5： 3811）, entitled ＂Functional and molecular features of the ealmodulin-interacting protein IQCG required for haematopoiesis in zebrafish＇.     

Agonist-bound structure of the human P2Y12 receptor

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Zhao Qiang and Prof. Wu Beili＇s laboratories at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, reported the crystal structure of the human P2Y12 receptor bound to an agonist, which was published in Nature （2014, 509（7498）： 119--122）.     

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Zhao Qiang＇s laboratory at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, reported the crystal structure of the human P2Y12 receptor in complex with an anlithrombotic drug, which was published in Nature （2014, 509（7498）. 115-8）.     

China＇s bullet trains facilitate market integration and mitigate the cost of mega city growth

The advent of bullet trains in China may spur social benefits for the nation＇s citizens, a recent study published in PNAS （Proceedings of the National Academy of Sciences of the United States of America, PNAS plus） suggests. The authors, Zheng Siqi （Tsinghua University, China） and Matthew E.     

Dynamic reassortments model of the human-infecting influenza A （H7N9） virus

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. George F. Gao＇s laboratory at the CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, with collaborators reported the genetic heterogeneity of the human-infecting influenza A （H7N9） virus and posed virus dynamic reassortments model, which was published in Nature Communications （2014, 5. 3142）.     

Reactions of xenon with iron and nickel are predicted in the Earth＇s inner core

With the support by the National Natural Science Foundation of China （Grant Nos. 11274136, 11025418 and 91022029） and the Ministry of Science and Technology （the National Basic Research Program of China, Grant No. 2011CB808200）, the research group led by Prof. Ma Yanming and Prof. Zou Guangtian at the State Key Laboratory of Superhard Materials, Jilin University, reported that the chemical reaction of Xe and Fe/Ni takes place under conditions found in the Earth＇s inner core, leading to the formation of inter-metallic compounds of XeFe3 and XeNi3. The result was published in Nature Chemistry （ 2014, 6（7）： 644-648）.