Ⅱ型糖尿病动物模型及其进展

近年来，糖尿病，尤其是Ⅱ型糖尿病发病率上升很快，对糖尿病的防治已成为医学科学工作者的一个重要课题。合适的糖尿病模型无疑可对人类糖尿病研究提供重要线索。本文对Ⅱ型糖尿病动物模型的现状及相关进展综述如下。１实验性糖尿病是指运用理化、生物等致病因素作用于动...     

绞股蓝多糖对2型糖尿病大鼠血糖的影响及其机制初步研究

目的：研究绞股蓝多糖对实验性2型糖尿病大鼠血糖、血脂的影响及其可能的机制。方法：采用Wistar大鼠高脂高糖饲料结合小剂量链脲佐菌素建立2型糖尿病大鼠模型,通过测定空腹血糖(FBG)和葡萄糖耐量,观察灌胃给予绞股蓝多糖对糖尿病大鼠的治疗作用,同时测定大鼠的血清胰岛素(Ins)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及部分抗氧化系统相关指标。结果：给予绞股蓝多糖后FBG明显降低,葡萄糖耐量曲线明显降低。此外,绞股蓝多糖可明显降低2型糖尿病大鼠的血清TC、TG、LDL和丙二醛水平,提高模型鼠的血清Ins、HDL、超氧化物歧化酶活性。结论：绞股蓝多糖对实验性糖尿病大鼠有明显的降血糖、降血脂作用,其作用可能与增加Ins水平,增强抗氧化能力有关。     

2型糖尿病患者血管并发症与凝血指标变化的分析

目的：研究2型糖尿病患者凝血四项指标的变化，以探讨其与血管病变的关系。方法：选病史5年以上2型糖尿病患者48例，年龄38-78岁，本组糖尿病患者血糖控制不佳，均有血管并发症；相应年龄对照人群48例。分别测定血浆凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、凝血酶时间（TT）。纤维蛋白原（FIB）、血清空腹血糖（GLU）水平。结果：2型糖尿病患者的血浆FIB水平较健康对照组升高；Am较正常对照组缩短。上述指标的变化与空腹血糖水平无关。结论：2型糖尿病患者存在凝血功能的紊乱，而凝血功能紊乱可能是导致患者血管并发症的重要原因之一。     

糖尿病小鼠胰腺腺泡细胞的超微结构和酶原颗粒的定量分析

本文用四氧嘧啶将小鼠建造成糖尿病动物模型。８周后，取胰尾组织作电镜观察，对腺泡细胞的超微结构和酶原颗粒的定量分析进行了研究。结果表明：糖尿病模型小鼠胰腺腺泡细胞中粗面内质网扩张、脱颗粒；线粒体峪紊乱或断裂；胞浆内出现许多髓样小体；酶原颗粒数（Ｎ值）减少（Ｐ＜０．０１），体密度（Ｖｖ值）降低（Ｐ＜０．０１）。显示：实验性糖尿病小鼠胰腺腺泡细胞超微结构和酶原的合成受到一定程度的损害。     

开搏通治疗自发性高血压糖尿病大鼠对肾功能的影响

目的：研究系统性高血压在糖尿病机理中的作用，以及血管紧张素转换酶抑制剂开搏通治疗自发性高血压（ＳＨＲ）糖尿病（ＤＭ）大鼠对肾功能的影响。方法：建立起自发性高血压大鼠链脲菌素（ＳＴＺ）诱导的糖尿病动物模型（ＳＨＲ＋ＤＭ），设立开治疗组，常规三联降压组（利血平＋肼苯哒嗪＋双氢克尿噻）、未治疗组及正常对照组，测定４周及１６周时肾功能包括尿白蛋白排泄量、肌酐清除率以及肾小球面积。结果：与正常血压ＷＫＹ大鼠     

大理学院学报2003年总目次

第1期医学类基础医学实验性糖尿病动物模型制备及指标测定评价……………………………………彭芳 ,杨远华(1)大理市小兽类哺乳动物膜壳绦虫感染情况调查…………………………李伟 ,申丽洁 ,罗志勇等(4)临床医学实验性草鱼胆中毒肾脏和肝脏损害的病理表现……………………何敏华 ,吴建新 ,钮荣祥等(7)急性白血病化疗后骨髓组织印片与涂片的同步观察…………………顾凤兰 ,李永萍 ,杨跃煌(9)老年高血压患者血压变化与血K ,Na 关系探讨……………………赵义娟 ,杨庆明 ,李旭明等(11)原发性高血压患者血压变异性与心率平均动脉压乘积的临床分…     

实验性糖尿病大鼠建模常用方法

在研究糖尿病的药物治疗当中,建立合适的动物模型是非常重要的,它可以帮助我们了解药物对疾病的防治机制、药物效应和不良反应,为药物的临床应用提供依据。目前糖尿病建模方法有很多,但各具优缺点,所以根据不同的实验需要选择合适的建模方法就显得极为重要。本文就国内常用的几种实验性糖尿病大鼠建模方法的特点及注意事项做一综述。     

我校93级学生体质某些指标参数的分析

本分析了我校９３级学生体质的某些指标。结果表明：９３级学生的身体形态发育水平尚可，速度素质、力量素质较好，而耐力素质、肺通气功能、男生的胸廓发育水平较差，为我校体系教学提供实验性依据。     

抗肿瘤药物动物模型的评价

目的：探讨抗肿瘤药物动物模型研究的新进展。方法：综合分析国内外研究现状并加以归纳。结果：抗肿瘤药物动物模型发展较快,并各有其特点。结论：抗肿瘤动物模型在抗肿瘤药物的研究中,具有不可替代的作用。     

魔芋低聚糖对小鼠实验性高脂血症防治作用的研究

为研究魔芋低聚糖对小鼠实验性高脂血症的降低脂作用,采用灌胃法建立小鼠高脂血症模型及磨芋低聚糖实验组,测定多项生化指标。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

橡胶颗粒沥青混合料低温抗裂性试验研究

以AC-13级配为基础,将橡胶颗粒代替部分集料掺入混合料中,以低温弯曲试验为评价方法对不同橡胶颗粒掺量下沥青混合料的低温抗裂性进行研究,并引入应变能密度值对混合料的低温抗裂性进行综合评价.试验结果表明:橡胶颗粒沥青混合料试件的破坏微应变均超过2 300,满足冬寒区的技术指标;无论是否掺加橡胶颗粒,随着温度的下降,沥青混合料破坏时的最大弯拉强度增大,弯拉应变降低,劲度模量增大;弯曲应变能密度在胶粒掺量为1%左右时具有较大的弯曲应变能密度值,此时橡胶颗粒沥青混合料具有较好的低温抗裂性.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Quantitative trait loci （QTLs） for quality traits related to protein and starch in wheat

Quality traits in wheat （Triticum aestirum L.） were studied by quantitative trait locus （QTL） analysis in a recombinant inbred line （RIL） population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross （ChSh）. Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99-40.52% of phenotypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1 D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster including protein and starch traits on chromosome 1D.