甲氨蝶呤联合中药治疗异位妊娠的临床观察

目的:观察甲氨蝶呤联合中药治疗异位妊娠的疗效.方法:将符合保守治疗的104例异位妊娠患者随机分为2组,每组52人,其中观察组:甲氨蝶呤50 mg/m2加入生理盐水100 mL单次静脉滴注并口服中药;对照组:甲氨蝶呤50 mg/m2加入生理盐水100 mL单次静脉滴注.比较两组的有效率、血β绒毛膜促性腺激素(β-HCG)降至正常时间、住院时间及副反应情况等.结果:有效率观察组96.15%,对照组80.77%,差异有统计学意义(P＜0.05).观察组较对照组能明显缩短血β-HCG降至正常时间(P＜0.01),减少住院日(P＜0.01).两组副反应相比,差异无统计学意义.结论:甲氨蝶呤联合中药治疗异位妊娠可缩短和减少氨甲喋呤重复用药,不增加副反应.     

人原发性肝癌中p16,p15基因CpG岛甲基化研究

目的　检测人原发性肝癌中 p16和 p15基因 5’启动子区CpG岛的异常甲基化 ,并分析其与人原发性肝癌发生发展的关系 ,探索其在临床早期基因诊断和治疗中的意义 .方法　用敏感的甲基化特异性PCR检测 2 0例人原发性肝癌患者癌组织、癌旁组织和远癌正常组织中p16 ,p15基因5’CpG岛的甲基化状况 ,统计分析这两个基因 5’CpG岛甲基化与肝癌病理特征的相关性 .结果　2 0例原发性肝癌肝癌组织中 p16和 p15基因 5’CpG岛分别有 6 5 %(13/2 0 )和 5 0 %(10 /2 0 )异常甲基化 ;癌旁组织中 p16和 p15基因 5’CpG岛分别有 6 0 %(12例 )和 4 0 %(8例 )异常甲基化 ;远癌正常组织中p16和 p15基因 5’CpG岛分别有 35 %(7例 )和 2 5 %(5例 )异常甲基化 .p16 ,p15基因 5’CpG岛甲基化在癌组织和癌组织旁、癌组织和远癌组织中均有相关性 .两个基因 5’CpG岛异常甲基化与临床病理特征无显著相关性 .结论　p16和 p15基因 5’CpG岛异常甲基化在人原发性肝癌中频率很高 ,可能在肝癌发生发展中扮演了重要角色 ;而...     

小剂量阿糖胞苷、高三尖杉酯碱与G-CSF治疗急性非淋巴细胞白血病(附16例疗效观察)

目的探讨治疗急性非淋巴细胞白血病的方法.方法对我科收治的16例急性非淋巴细胞白血病,应用小剂量阿糖胞苷和高三尖杉碱(HA方案)与G-CSF联合方案治疗.结果完全缓解率31.25%(5/16),占总数(CR+PR)68.75%(11/16).结论本方案可明提高急性非淋巴细胞白血病的缓解率,对过渡到标准剂量强化治疗创造机会具有积极的意义,可作为治疗急性非淋巴细胞白血病较好的方案.     

小剂量阿糖胞苷、高三尖杉酯碱与G-CSF治疗急性非淋巴细胞白血病(附16例疗效观察)

目的探讨治疗急性非淋巴细胞白血病的方法.方法对我科收治的16例急性非淋巴细胞白血病,应用小剂量阿糖胞苷和高三尖杉碱(HA方案)与G-CSF联合方案治疗.结果完全缓解率31.25%(5/16),占总数(CR+PR)68.75%(11/16).结论本方案可明提高急性非淋巴细胞白血病的缓解率,对过渡到标准剂量强化治疗创造机会具有积极的意义,可作为治疗急性非淋巴细胞白血病较好的方案.     

达那唑联合甲氨蝶呤治疗成人难治性特发性血小板减少性紫癜的临床观察

目的 总结达那唑联合甲氨蝶呤治疗成人慢性难治性特发性血小板减少性紫癜(ITP)的临床效果.方法 回顾性分析治疗19例慢性难治性ITP的临床资料.结果 12例显效,4例良效,1例进步,2例无效.随访3～38个月,均存活.结论 达那唑联合甲氨蝶呤治疗成人慢性难治性ITP疗效满意,未见明显不良反应.     

伊立替康联合5-FU/CF治疗晚期结直肠癌的临床观察

目的:观察伊立替康(CPT-11)联合5-FU/CF治疗晚期结直肠癌的疗效及毒性反应.方法:2001年2月～2005年8月对晚期结直肠癌采用伊立替康(CPT-11)联合5-FU/CF方案化疗.入组患者均经病理组织学证实,有可测量病灶.具体为伊立替康250mg/m2iv第1天,CF200mg/m2iv第1～5天,5-FU500mg/m2iv第1～5天.21d为1个周期,化疗2个周期后评价疗效及毒性反应.结果:可评价疗效者30例,其中完全缓解(CR)2例,部分缓解(PR)11例,RR占43.3%,稳定(SD)14例,占46.7%,进展(PD)3例.临床受益率为83.3%,疼痛缓解率83.3%.中位肿瘤进展时间7.2月,中位生存期13.8月.主要副反应为迟发性腹泻和中性粒细胞减少,未出现治疗相关性死亡.结论:CPT-11联合5-FU/CF方案治疗晚期结直肠癌患者有较好疗效,毒副反应可以接受.     

甲氨蝶呤配伍大剂量米非司酮治疗异位妊娠86例临床效果观察

目的:探讨甲氨蝶呤配伍大剂量米非司酮用于异位妊娠治疗的临床效果.方法:治疗的第一天应用甲氨蝶呤50 mg,单次臀部肌注.同时口服米非司酮100 mg/次,12 h1次,共服3 d,6次总剂量600 mg,服药前后2 h 禁食水.结果:联合用药成功率为94.1%,副反应产生率8.1%.结论:[HT SS]使用甲氨蝶呤配伍大剂量米非司酮治疗异位妊娠,可增加疗效,不增加副反应.     

治疗放射性肺炎的润肺通络法

目的　观察以润肺通络为主治疗放射性肺炎之疗效 .方法　采用中药润肺通络的基本方为沙参、麦冬、玉竹、天花粉、桑叶、鱼腥草、杏仁、紫菀、黄芩、丹皮、丹参、赤芍 ,同时用西药抗生素、肾上腺皮质激素、支气管扩张剂治疗放射性肺炎 ,共 17例 ,并设对照组对照观察 .结果　治疗组治愈率 (5 2 .9% )明显高于对照组 (16.7% ) ,有显著性差异 (χ2 =3.99,P <0 .0 5 ) .治疗组总有效率(88.2 % )明显高于对照组 (4 1.7% ) ,有极显著差异 (χ2 =6.70 ,P <0 .0 1) .结论　润肺通络法对放射性肺炎有明显的治疗作用 ,临床观察中未见明显的不良反应 .     

中药治疗胆汁反流性胃炎36例

目的探讨胆汁反流性胃炎的中药治疗效果.方法分析近年来我们用中药旋复代赭汤加减治疗胆汁反流性胃炎36例的临床资料.结果36例中,治愈23例(63.8%),有效11例(30.5%),无效2例(5.5%),总有效率达94.4%.结论中药治疗胆汁反流性胃炎,疗效好,无毒副作用和不良反应.     

中药治疗胆汁反流性胃炎36例

目的探讨胆汁反流性胃炎的中药治疗效果.方法分析近年来我们用中药旋复代赭汤加减治疗胆汁反流性胃炎36例的临床资料.结果36例中,治愈23例(63.8%),有效11例(30.5%),无效2例(5.5%),总有效率达94.4%.结论中药治疗胆汁反流性胃炎,疗效好,无毒副作用和不良反应.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

橡胶颗粒沥青混合料低温抗裂性试验研究

以AC-13级配为基础,将橡胶颗粒代替部分集料掺入混合料中,以低温弯曲试验为评价方法对不同橡胶颗粒掺量下沥青混合料的低温抗裂性进行研究,并引入应变能密度值对混合料的低温抗裂性进行综合评价.试验结果表明:橡胶颗粒沥青混合料试件的破坏微应变均超过2 300,满足冬寒区的技术指标;无论是否掺加橡胶颗粒,随着温度的下降,沥青混合料破坏时的最大弯拉强度增大,弯拉应变降低,劲度模量增大;弯曲应变能密度在胶粒掺量为1%左右时具有较大的弯曲应变能密度值,此时橡胶颗粒沥青混合料具有较好的低温抗裂性.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

Quantitative trait loci （QTLs） for quality traits related to protein and starch in wheat

Quality traits in wheat （Triticum aestirum L.） were studied by quantitative trait locus （QTL） analysis in a recombinant inbred line （RIL） population, a set of 131 lines derived from Chuan 35050 × Shannong 483 cross （ChSh）. Grains from RILs were assayed for 21 quality traits related to protein and starch. A total of 35 putative QTLs for 19 traits with a single QTL explaining 7.99-40.52% of phenotypic variations were detected on 10 chromosomes, 1D, 2A, 2D, 3B, 3D, 5A, 6A, 6B, 6D, and 7B. The additive effects of 30 QTLs were positive, contributed by Chuan 35050, the remaining 5 QTLs were negative with the additive effect contributed by Shannong 483. For protein traits, 15 QTLs were obtained and most of them were located on chromosomes 1 D, 3B and 6D, while 20 QTLs for starch traits were detected and most of them were located on chromosomes 3D, 6B and 7B. Only 7 QTLs for protein and starch traits were co-located in three regions on chromosomes 1D, 2A and 2D. These protein and starch trait QTLs showed a distinct distribution pattern in certain regions and chromosomes. Twenty-two QTLs were clustered in 6 regions of 5 chromosomes. Two QTL clusters for protein traits were located on chromosomes 1D and 3B, respectively, three clusters for starch traits on chromosomes 3D, 6B and 7B, and one cluster including protein and starch traits on chromosome 1D.