Regenerative medicine and human models of human disease

Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.     

人类自然情结与人居环境设计研究

系统地研究了人类自然情结产生的生物学、生态学、环境学、心理学、人类学、社会学根源,提出自然情结具有永恒性的特点。根据对人类自然情结产生及现代人居环境的影响不同,把自然因素划分为核心要素和外围要素,把人居环境分为核心空间和外围空间。核心空间包括城市、社区(城镇)和建筑三个层次,对人类的综合作用最大,又称为人性空间,且其中的核心要素往往是可设计的,必须给予高度的重视。最后,提出人居环境基本人性法则。     

人体生理学在企业人力资源开发中的应用

运用仿生学基本原理,从人体生理学细胞物质转运入手,对人力资源层次上的企业人力资源开发方法、部门系统层次上的人力资本的来源和人力资源系统开发、整体水平上的人力资源的管理开发和激励开发,以及对教育、培训和人力资源配置在企业人力资源开发中的作用进行研究,以期形成一套系统的企业人力资源开发方法,发挥企业在其人力资源开发中的作用.     

A survey of human leukaemias for sequences of a human retrovirus

Human T-cell leukaemia-lymphoma virus (HTLV) is an exogenous human retrovirus distinct from all known animal retroviruses. HTLV is closely linked to a subtype of adult T-cell malignancies and except for isolated cases, has not been found associated with any other form of leukaemia, lymphoma or other cancers (see refs 1, 2 for review). HTLV can be transmitted to cord blood T lymphocytes in vitro and the infected cells exhibit characteristics of transformed neoplastic T cells. We have recently cloned DNA sequences derived from approximately 1 kilobase (kb) of the 5' and 3' termini of the HTLV genome, as well as a 4-5-kb defective HTLV provirus flanked by cellular sequences. The availability of these probes has enabled us to carry out a limited survey of different fresh or cultured cells from patients of different lymphoid and myeloid malignancies for HTLV-related DNA sequences. The results presented here show that cells from all Japanese patients with adult T-cell leukaemia and several patients with various mature T-cell malignancies from elsewhere contained one or more copies of a highly conserved HTLV genome. The infected cells are of clonal origin. Fresh cells from 1 of the 10 myeloid leukaemic patients contained exogenous DNA sequences distantly related to HTLV.     

Motion-deblurring in human vision

If photographs are taken of moving objects at slow shutter speeds the images of the objects are blurred. In human vision, however, we are not normally conscious of blur from moving objects despite the fact that the temporal response of the photoreceptors is sluggish. It has been suggested that there are motion-deblurring mechanisms specifically to aid the visual system in the analysis of the shape of retinally moving targets. Models of motion deblurring have been influenced by the finding that certain very precise spatial pattern discriminations are unaffected by motion. An example is vernier hyperacuity, in which the observer must detect the direction of offset between two lines with abutting ends. With a stationary stimulus, observers can detect a vernier cue of less than 10 arcsec and acuity is unaffected by retinal-image motion of up to 3 deg s-1 We confirm this finding, but provide evidence against any general deblurring mechanism by showing that another kind of hyperacuity, discrimination of the distance between two parallel lines (spatial interval acuity), is interfered with by motion. This argues against a general deblurring mechanism, such as a neural network 'shifter circuit', and we point out that the high level of vernier acuity for moving stimuli is susceptible to an alternative explanation.