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Robert W. Buckheit III Maria Salgado Karen O. Martins Joel N. Blankson 《Cellular and molecular life sciences : CMLS》2013,70(6):1009-1019
The mechanisms by which a small percentage of HIV-1 infected individuals known as elite suppressors or controllers are able to control viral replication are not fully understood. Early cases of viremic control were attributed to infection with defective virus, but subsequent work has demonstrated that infection with a defective virus is not the exclusive cause of control. Replication-competent virus has been isolated from patients who control viral replication, and studies have demonstrated that evolution occurs in plasma virus but not in virus isolates from the latent reservoir. Additionally, transmission pair studies have demonstrated that patients infected with similar viruses can have dramatically different outcomes of infection. An increased understanding of the viral factors associated with control is important to understand the interplay between viral replication and host control, and has implications for the design of an effective therapeutic vaccine that can lead to a functional cure of HIV-1 infection. 相似文献
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Alais S Soto-Rifo R Balter V Gruffat H Manet E Schaeffer L Darlix JL Cimarelli A Raposo G Ohlmann T Leblanc P 《Cellular and molecular life sciences : CMLS》2012,69(8):1331-1352
The cellular prion protein PrP(C)/CD230 is a GPI-anchor protein highly expressed in cells from the nervous and immune systems and well conserved among vertebrates. In the last decade, several studies suggested that PrP(C) displays antiviral properties by restricting the replication of different viruses, and in particular retroviruses such as murine leukemia virus (MuLV) and the human immunodeficiency virus type 1 (HIV-1). In this context, we previously showed that PrP(C) displays important similarities with the HIV-1 nucleocapsid protein and found that PrP(C) expression in a human cell line strongly reduced HIV-1 expression and virus production. Using different PrP(C) mutants, we report here that the anti-HIV-1 properties are mostly associated with the amino-terminal 24-KRPKP-28 basic domain. In agreement with its reported RNA chaperone activity, we found that PrP(C) binds to the viral genomic RNA of HIV-1 and negatively affects its translation. Using a combination of biochemical and cell imaging strategies, we found that PrP(C) colocalizes with the virus assembly machinery at the plasma membrane and at the virological synapse in infected T cells. Depletion of PrP(C) in infected T cells and microglial cells favors HIV-1 replication, confirming its negative impact on the HIV-1 life cycle. 相似文献
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Ophélie Cosnefroy Anaïs Jaspart Christina Calmels Vincent Parissi Hervé Fleury Michel Ventura Sandrine Reigadas Marie-Line Andréola 《Cellular and molecular life sciences : CMLS》2013,70(13):2411-2421
Higher eukaryotic organisms have a variety of specific and nonspecific defense mechanisms against viral invaders. In animal cells, viral replication may be limited through the decrease in translation. Some viruses, however, have evolved mechanisms that counteract the response of the host. We report that infection by HIV-1 triggers acute decrease in translation. The human protein kinase GCN2 (eIF2AK4) is activated by phosphorylation upon HIV-1 infection in the hours following infection. Thus, infection by HIV-1 constitutes a stress that leads to the activation of GCN2 with a resulting decrease in protein synthesis. We have shown that GCN2 interacts with HIV-1 integrase (IN). Transfection of IN in amino acid-starved cells, where GCN2 is activated, increases the protein synthesis level. These results point to an as yet unknown role of GCN2 as an early mediator in the cellular response to HIV-1 infection, and suggest that the virus is able to overcome the involvement of GCN2 in the cellular response by eliciting methods to maintain protein synthesis. 相似文献
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Structural aspects of rabies virus replication 总被引:2,自引:0,他引:2
Albertini AA Schoehn G Weissenhorn W Ruigrok RW 《Cellular and molecular life sciences : CMLS》2008,65(2):282-294
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Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3 总被引:1,自引:1,他引:0
Ji-Won Jung Seunghee Lee Min-Soo Seo Sang-Bum Park Andreas Kurtz Soo-Kyung Kang Kyung-Sun Kang 《Cellular and molecular life sciences : CMLS》2010,67(7):1165-1176
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Morrison BE Majdzadeh N D'Mello SR 《Cellular and molecular life sciences : CMLS》2007,64(17):2258-2269
Neurodegenerative disease strikes millions worldwide and there is mounting evidence suggesting that underlying the onset and
progression of these debilitating diseases is inappropriate neuronal apoptosis. Recent reports have implicated a family of
proteins known as histone deacetylases (HDACs) in various neuronal processes including the neuronal death program. Initial
headway in this field has been made largely through the use of broad-spectrum HDAC inhibitors. In fact, pharmacological inhibition
of HDAC activity has been shown to protect neurons in several models of neurodegeneration. The observation that HDAC inhibitors
can have opposing effects in different paradigms of neurodegeneration suggests that individual members of the HDAC protein
family may play distinct roles that could depend on the specific cell type under study. The purpose of this review is to detail
work involving the use of HDAC inhibitors within the context of neurodegeneration and examine the roles of individual HDAC
members in the nervous system with specific focus on neuronal cell death.
Received 25 January 2007; received after revision 3 April 2007; accepted 26 April 2007 相似文献
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Lactoferrin 总被引:4,自引:0,他引:4
The first function attributed to lactoferrin (Lf), an iron binding protein belonging to the non-immune natural defences, was antimicrobial activity that depended on its capacity to sequester iron. Iron-independent microbicidal activities, requiring direct interaction between this cationic protein and microbial surface components, were later demonstrated. Many other anti-microbial and anti-viral functions have since been ascribed to Lf. In mucosal secretions, iron and Lf modulate the motility and aggregation of pathogenic bacteria. Lf inhibits bacterial adhesion on abiotic surfaces through ionic binding to biomaterials, or specific binding to bacterial structures or both. Lf inhibition of bacterial adhesion to host cells requires Lf binding to bacteria and/or host cells. Lf hinders microbial internalization by binding to both glycosaminoglycans and bacterial proteins which can be degraded by Lf-mediated proteolysis. Moreover, Lf internalisation and localisation to the host cell nuclei could modulate bacterial entry into cells through gene regulation. Finally, the capability of Lf to exert antiviral activity, through its binding to host cells and/or viral particles, strengthens the idea that it is an important brick in the mucosal wall, effective against both microbial and viral attacks. 相似文献
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Mariana Gomez-Smith Zhaohong Qin Xun Zhou Sarah C. Schock Hsiao-Huei Chen 《Cellular and molecular life sciences : CMLS》2010,67(6):949-957
Granulocyte colony-stimulating factor (GCSF) is currently in clinical trials to treat neurodegenerative diseases and stroke.
Here, we tested whether LIM domain only 4 protein (LMO4), a hypoxia-inducible gene that protects neurons from ischemic injury,
could modulate the neuroprotective effect of GCSF. We showed that GCSF treatment acetylates and phosphorylates Stat3, activates
expression of a Stat3-dependent anti-apoptotic gene, p27, and increases neuron survival from ischemic injury. LMO4 participates
in Stat3 signaling in hepatocytes and associates with histone deacetylase 2 (HDAC2) in cancer cells. In the absence of LMO4,
GCSF fails to rescue neurons from ischemic insults. In wild-type neurons, inhibition of HDAC promoted Stat3 acetylation and
the antiapoptotic effect of GCSF. In LMO4 null cortical neurons, expression of wild-type but not HDAC-interaction-deficient
LMO4 restored GCSF-induced Stat3 acetylation and p27 expression. Thus, our results indicate that LMO4 enhances GCSF-induced
Stat3 signaling in neurons, in part by sequestering HDAC. 相似文献