| 富勒烯及其衍生物对小鼠卵母细胞成熟和激活的作用 |
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| 引用本文： | 谭信,郭秀敏,杨新林,乔新歌.富勒烯及其衍生物对小鼠卵母细胞成熟和激活的作用[J].北京理工大学学报,2006,26(11):1030-1034. |
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| 作者姓名： | 谭信 郭秀敏 杨新林 乔新歌 |
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| 作者单位： | 北京理工大学,生命科学与技术学院,北京,100081;北京理工大学,生命科学与技术学院,北京,100081;北京理工大学,生命科学与技术学院,北京,100081;北京理工大学,生命科学与技术学院,北京,100081 |
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| 基金项目： | 北京市自然科学基金
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高等学校博士学科点专项科研项目 |
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| 摘 要： | 为探索富勒烯及其水溶性衍生物对哺乳动物卵母细胞减数分裂的作用,使用富勒烯膦酸衍生物(2P)、富勒烯-PVP和富勒醇作用于体外培养的小鼠GV期卵母细胞和超排卵母细胞,通过观察第一极体排出率和原核形成率以判断卵母细胞的成熟和激活,并探讨光照对这一作用的影响.结果表明,在光照和非光照下,富勒烯的PVP水溶液、富勒醇对卵母细胞的成熟没有明显影响,而2P在光照下对卵母细胞的成熟和孤雌激活具有明显抑制作用,其作用有浓度依赖性.
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| 关 键 词： | 富勒烯 卵母细胞 减数分裂 |
| 文章编号： | 1001-0645(2006)11-1030-05 |
| 收稿时间： | 2006/5/11 0:00:00 |
| 修稿时间： | 2006年5月11日 |
Effects of Fullerene and Its Derivatives on Oocyte Maturation and Activation |
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| TAN Xin,GUO Xiu-min,YANG Xin-lin and QIAO Xin-ge.Effects of Fullerene and Its Derivatives on Oocyte Maturation and Activation[J].Journal of Beijing Institute of Technology(Natural Science Edition),2006,26(11):1030-1034. |
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| Authors: | TAN Xin GUO Xiu-min YANG Xin-lin and QIAO Xin-ge |
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| Institution: | School of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,China;School of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,China;School of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,China;School of Life Science and Technology,Beijing Institute of Technology,Beijing 100081,China |
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| Abstract: | In order to determine the effects of fullerene and its water-soluble derivatives on mammal oocyte meiosis,a water-soluble phosphonic acid derivative of fullerene(2P),fullerene-PVP solution and fullerenol were used to act on mouse GV stage and superovulated oocytes in vitro under irradiation.The maturation and activation of the oocytes were determined by their first polar body rate and pronuclear rate,respectively.The results indicated that fullerene-PVP solution and fullerenol have no obvious effect on oocyte in vitro maturation;but that 2P inhibits the oocyte maturation and parthenogenetic activation under irradiation.The effect of 2P was dose-dependent. |
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| Keywords: | fullerene oocyte meiosis |
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