Aspirin: recent developments |
| |
| Authors: | O Yasuda Y Takemura H Kawamoto H Rakugi |
| |
| Institution: | (1) Department of Geriatric Medicine, Osaka University Graduate School of Medicine 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan |
| |
| Abstract: | Aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1, preventing the production of thromboxane
A
2 in platelets. Through this inhibition of platelet function, aspirin is considered as a preventative of ischemic diseases
such as coronary and cerebral infarction. However, many studies have revealed that aspirin has other beneficial actions in
addition to its anti-platelet activity. For example, aspirin may confer some benefit against colorectal cancer. Here, we discuss
the involvement of inflammation in atherosclerosis and how aspirin exerts its beneficial actions in atherosclerotic diseases
and cancer.
Received 30 September 2007; received after revision 31 October 2007; accepted 6 November 2007 |
| |
| Keywords: | Aspirin atherosclerosis cyclooxygenase lipoxin nuclear factor-κ B nitric oxide |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
