Der Einfluss von Adrenalin auf das Verhalten des zellulären Kalziums während der K-Depolarisation des Herzmuskels von Meerschweinchen

Summary The effect of adrenaline on the cellular calcium exchange during the K-depolarization of myocardium was studied in isolated left auricles of guinea-pigs by means of the⁴⁵Ca. Increasing the extracellular K-concentration from 2.7–30 mM without corresponding reduction in sodium concentration results in a depression of contraction strength of the myocardium when current is applied. The depression is immediately reversible by using adrenaline. This was associated with a significant increase of the⁴⁵Ca exchange.