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| Advances in mammalian spermatogonial stem cell transplantation | |
| 作者姓名： | ZHANG Xueming LI Dexue YUE Zhanpeng LI Lingling YU Jiaao |
| 作者单位： | Faculty of Military Veterinary, Quarter-Master University of PLA, Changchun 130062, China,Academy of Military Medical Sciences, Beijing 100085, China,Faculty of Military Veterinary, Quarter-Master University of PLA, Changchun 130062, China,Qian Wei Hospital of Jilin Province, Changchun 130021, China,The First Hospital of Jilin University, Changchun 130021, China |
| 基金项目： | Supported by the National Natural Science Foundation of China (Grant No. 30200195), the Program of Science & Technology Development of Jilin Province (Grant No. 20010555) and the Medicine & Health Science Research Foundation of PLA (Grant No. 01MA204) |
| 摘 要： | Spermatogonial stem cell (SSC) transplantation is a novel technique by which testicular cells from normal, transgenic or mutant donor are introduced into the seminiferous tubules of recipient testes through microinjection. Subsequently, donor SSCs survive,migrate, anchor and proliferate in the recipient testis, furthermore, initiate spermatogenesis and even produce sperms capable of fertilization. This technique provides a new approach for the researches of spermatogenesis mechanism, regeneration of spermatogenesis in sterile individuals and reproduction of transgenic animals. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of SSC biology. The article provides a comprehensive overview of this technique and its multiple applications in basic science and medicine. And the perspective direction of this field in the near future is proposed. |
| 关 键 词： | spermatogonial stem cell transplantation application |
Advances in mammalian spermatogonial stem cell transplantation |
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| ZHANG Xueming,LI Dexue,YUE Zhanpeng,LI Lingling,YU Jiaao.Advances in mammalian spermatogonial stem cell transplantation[J].Progress in Natural Science,2004,14(6):467-471. | |
| Authors: | Zhang Xueming LI Dexue YUE Zhanpeng Li Lingling YU Jiaao |
| Institution: | 1. Faculty of Military Veterinary, Quarter-Master University of PLA, Changchun 130062, China 2. Academy of Military Medical Sciences, Beijing 100085, China 3. Qian Wei Hospital of Jilin Province, Changchun 130021, China 4. The First Hospital of Jilin University, Changchun 130021, China |
| Abstract: | Spermatogonial stem cell (SSC) transplantation is a novel technique by which testicular cells from normal, transgenic or mutant donor are introduced into the seminiferous tubules of recipient testes through microinjection. Subsequently, donor SSCs survive,migrate, anchor and proliferate in the recipient testis, furthermore, initiate spermatogenesis and even produce sperms capable of fertilization. This technique provides a new approach for the researches of spermatogenesis mechanism, regeneration of spermatogenesis in sterile individuals and reproduction of transgenic animals. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of SSC biology. The article provides a comprehensive overview of this technique and its multiple applications in basic science and medicine. And the perspective direction of this field in the near future is proposed. |
| Keywords: | spermatogonial stem cell transplantation application |
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