Die Wirkung von Theophyllin auf den cellulären Ca-Stoffwechsel des Warmblüterherzens |
| |
Authors: | H Scholz |
| |
Institution: | (1) Pharmakologisches Institut der Universität, D-65 Mainz, Deutschland |
| |
Abstract: | Summary In isolated, electrically driven, left guineapig atria, theophylline (5×10–4 g/ml) increased the rate of45Ca uptake and release without affecting the total myocardial Ca content and the amount of exchangeable cellular Ca. In sheep and calf heart preparations, theophylline (10–4–10–3 g/ml) increased Ca inward current during excitation (as examined indirectly by Ca dependent changes of membrane potential in TTX-containing solutions) as well as tension development. It is concluded that the positive inotropic effect of theophylline in mammalian hearts is due to an increase in Ca influx during the excitation process.
Mit Unterstützung der Deutschen Forschungsgemeinschaft. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|