Synthetic simulation of nonribosomal peptide biosynthesis. A dual role of alkylthiol esters in peptide synthesis |
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| Authors: | S Yamada Y Yokoyama T Shioiri |
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| Institution: | (1) Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, 113 Tokyo, (Japan) |
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| Abstract: | Summary Coupling of peptide alkylthiol esters with amino acid derivatives in the presence of pivalic acid or 2-hydroxypyridine proceeds without racemization. A dual role of alkylthiol esters as protective and reactive functions in peptide synthesis was well proved. |
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