| 红曲霉产HMG-CoA还原酶抑制剂的研究 |
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| 引用本文： | 缪莉.红曲霉产HMG-CoA还原酶抑制剂的研究[J].阜阳师范学院学报(自然科学版),2007,24(2):26-29. |
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| 作者姓名： | 缪莉 |
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| 作者单位： | 阜阳师范学院,生物系,安徽,阜阳,236041 |
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| 摘 要： | 采用薄层层析-紫外吸收光谱法对一株红曲霉产生的HMG-CoA还原酶抑制剂进行分析测定,并对其发酵条件进行研究.结果表明:该菌能产生洛伐他汀或其类似物.产物合成的适宜条件为:采用固体发酵培养基b,接种量5%~10%,变温培养.在这些条件下,固体发酵10 d,该菌株产生的酶抑制剂可达0.19%以上.
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| 关 键 词： | 红曲霉 HMG-CoA还原酶抑制剂 薄层层析 紫外吸收光谱 |
| 文章编号： | 1004-4329（2007）02-0026-04 |
| 收稿时间： | 2007-04-03 |
| 修稿时间： | 2007年4月3日 |
Study on HMG-CoA Reductase Inhibitors Produced by a Monascus sp. |
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| MIAO Li.Study on HMG-CoA Reductase Inhibitors Produced by a Monascus sp.[J].Journal of Fuyang Teachers College:Natural Science,2007,24(2):26-29. |
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| Authors: | MIAO Li |
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| Abstract: | By using TLC and UV-spectrum detection,HMG-CoA reductase inhibitors produced by a strain of Monacus sp were assayed,and the optimum fermentation conditions were studied as well.Lavostatin or its derivatives were detected in fermentation broth of the studied strain.The highest yield more than 0.19% was observed after solid state fermentation for ten days with 5%～10% inoculum and under two phases cultivation in which temperature was different. |
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| Keywords: | monascus HMG-CoA reductase inhibitors TLC UV-spectrum |
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