9,10-Dihydroergotamine: Production of antibodies and radioimmunoassay |
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Authors: | J Rosenthaler H Munzer |
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Institution: | (1) Pharmaceutical Division, Sandoz Ltd., CH-4002 Basel, (Switzerland) |
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Abstract: | Summary Antibodies against 9,10-dihydroergotamine (DHE) were produced by immunizing rabbits with a conjugate of 6-nor-6-carboxymethyl-9,10-dihydroergotamine and bovine serum albumin. A highly specific and sensitive radioimmunoassay for DHE has been developed.We are greatly indebted to Dr.T. Fehr for the synthesis of 6-nor-6-carboxymethyl-9,10-dihydroergotamine, and to Dr.E. Schreier for providing us with 9,10-dihydroergotamine-13-3H]-base of high specific activity. |
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