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| 肝硬化大鼠心肌病理研究 | |
| 引用本文： | 谭凯,张鹏宁,王天才. 肝硬化大鼠心肌病理研究[J]. 武汉科技大学学报(自然科学版), 2005, 28(4): 413-414 |
| 作者姓名： | 谭凯 张鹏宁 王天才 |
| 作者单位： | 1. 武汉科技大学,湖北,武汉,430062 2. 上海市第一人民医院,上海,200080 3. 华中科技大学,湖北,武汉,430030 |
| 摘 要： | 应用胆管结扎（BDL）复制肝硬化模型（C组n=6），用Masson，Toluidine blue染色及电镜观察心肌结构改变。发现C组较S组（假手术组，n=6）心肌间质胶原纤维、血管周围胶原纤维及肥大细胞数均显著增加，c组心肌间质纤维化和肥大细胞浸润。结果表明肝硬化存在心肌间质纤维化和肥大细胞浸润，可能参与肝硬化心肌病的发生。 |
| 关 键 词： | 大鼠 肝硬化 心肌病 胆管结扎 BDL 心肌结构 |
| 文章编号： | 1672-3090(2005)04-0413-02 |
| 收稿时间： | 2005-09-02 |
| 修稿时间： | 2005-09-02 |
Pathologic Changes in Cirrhotic Myocardium |
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| TAN Kai,ZHANG Peng-yu,WANG Tian-cai. Pathologic Changes in Cirrhotic Myocardium[J]. Journal of Wuhan University of Science and Technology(Natural Science Edition), 2005, 28(4): 413-414 | |
| Authors: | TAN Kai ZHANG Peng-yu WANG Tian-cai |
| Abstract: | Cirrhosis was induced by bile duct ligation(BDL) (C group,n=6);age and sex-matched sham operation rats were used as controls(S group,n=6).The structural changes were assessed using Masson's trichrome staining,Toluidine blue staining and transmission electronic microscopy.It was found that myocardial interstitial collagen,perivascular collagen,and mase cells(MC) count increased significantly in C vs S group.Electromicroscopy pointed to myocardial interstitial fibrosis and MC infiltration,whose presence in cirrhotic myocardium may have played a role in the pathogenesis of cirrhotic cardiomyopathy. |
| Keywords: | rat cirrhosis cardiomyopathy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |