Effects of dobutamine on cyclic AMP accumulation induced by the stimulation of dopamine receptors in rabbit retina in vitro |
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| Authors: | A. Forster P. J. Magistretti M. Schorderet |
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| Affiliation: | (1) Départment de pharmacologie, Ecole de Médecine, CH-1211 Genève 4, (Switzerland);(2) Present address: Institut d'Anesthésiologie, Hôpital cantonal, CH-1211 Genève;(3) Present address: A.V. Davis Center for Behavioral Neurobiology, The Salk Institute, P.O. Box 1809, 92112 San Diego, Ca, USA |
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| Abstract: | Summary Intact rabbit retinae were used for testing in vitro the potential activation of dopamine receptors by a new cardioactive sympathetic amine dobutamine. It was found that despite the structure relationship of dobutamine with other dopamine-analogs, the pharmacological action of this compound is not comparable to that of apomorphine, N-methyl-dopamine and/or ADTN.Acknowledgments. Supported by SNSF grant No. 3.327.078. The authors express their gratitude to Miss G. Allenbach for her excellent technical assistance and to Mr F. Pillonel for drawing the graphs. |
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