| 线粒体转录终止因子3在甲状腺癌中的表达及预后意义 |
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| 引用本文： | 孙美涛,赵恒宇,李晓燕,冯琛卓,熊伟. 线粒体转录终止因子3在甲状腺癌中的表达及预后意义[J]. 井冈山大学学报(自然科学版), 2022, 43(5): 36-43 |
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| 作者姓名： | 孙美涛 赵恒宇 李晓燕 冯琛卓 熊伟 |
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| 作者单位： | 杭州医学院基础医学与法医学院, 浙江, 杭州 310053;杭州医学院临床医学院, 浙江, 杭州 310053;大理大学基础医学院, 云南, 大理 671000 |
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| 基金项目： | 国家自然科学基金项目(82160516);浙江省教育厅计划项目一般科研项目(Y201942775、Y201941297);浙江省基础公益研究计划项目LGF22H080016);浙江省卫生厅高层次创新人才计划项目 |
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| 摘 要： | 对线粒体转录终止因子3（MTERF3）在甲状腺癌中的表达水平进行分析并评估其预后价值。从TCGA和GTEx等数据库提取甲状腺癌患者MTERF3的表达数据,探究MTERF3在甲状腺癌和癌旁组织中差异表达,分析差异表达对患者免疫细胞浸润和预后情况的影响,并明确MTERF3的临床意义。MTERF3在甲状腺癌中表达水平显著低于正常甲状腺组织,该基因在甲状腺癌中表达较低提示患者预后不良。MTERF3是甲状腺癌的预后标志物,是甲状腺癌诊断和治疗的潜在分子靶标。
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| 关 键 词： | 甲状腺癌 线粒体转录终止因子3 生物标志物 生物信息 |
| 收稿时间： | 2021-12-06 |
| 修稿时间： | 2022-05-12 |
EXPRESSION AND SIGNIFICANCE OF MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 3 IN THYROID CARCINOMA |
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| SUN Mei-tao,ZHAO Heng-yu,LI Xiao-yan,FENG Chen-zhuo,XIONG Wei. EXPRESSION AND SIGNIFICANCE OF MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 3 IN THYROID CARCINOMA[J]. Journal of Jinggangshan University(Natural Sciences Edition), 2022, 43(5): 36-43 |
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| Authors: | SUN Mei-tao ZHAO Heng-yu LI Xiao-yan FENG Chen-zhuo XIONG Wei |
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| Affiliation: | School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China;School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China; College of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China |
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| Abstract: | To analyze the expression level of mitochondrial transcription termination factor 3 (MTERF3) in thyroid carcinoma and evaluate its prognostic value. The data of the patients with thyroid carcinoma were extracted from TCGA and GTEx databases to explore the differential expression of MTERF3 in thyroid carcinoma and adjacent tissues. Then, the impact of differential expression on immune cell infiltration and prognosis was analyzed. Finally, the clinical significance of MTERF3 was clarified. The expression level of MTERF3 in thyroid cancer was significantly lower than that in normal thyroid tissue. The low expression of MTERF3 in thyroid cancer suggested that the prognosis of patients was poor. MTERF3 is a prognostic marker of thyroid cancer and a potential molecular target for the diagnosis and treatment of thyroid cancer. |
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| Keywords: | thyroid carcinoma mitochondrial transcription termination factor 3 biomarkers bioinformatics |
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