Agglutinins from aquatic insects—tumor cell agglutination activity |
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Authors: | H Kawauchi M Hosono Y Takayanagi K Nitta |
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Institution: | (1) Cancer Research Institute, Tohoku College of Pharmaceutical Sciences, Komatsushima 4-4-1, Aoba-Ku, 981 Sendai, (Japan) |
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Abstract: | Agglutinins were identified in whole body extracts of aquatic insects by means of murine tumor cell agglutination, using sarcoma 180 ascites, Ehrlich, and MM-46 cells. Screening revealed agglutinins in 5 of 10 of the larvae tested, and in 2 of 6 of the water-dwelling adult insects;Gerris paludum insularis andGyrinus japonicus. Only the agglutinin from adultG. paludum also agglutinated human erythrocytes. An ascites tumor was converted into a solid form in vivo after administration ofG. paludum agglutinin. The observation that these aquatic insect agglutinins preferentially agglutinate tumor cells has considerable implications in terms of anti-tumor effects such as inhibition of cell proliferation and metastasis.Deceased. |
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Keywords: | Agglutinin aquatic insect tumor cell agglutination hemagglutination antiproliferative effect Gerris paludum |
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