Acylfulvenes,a new class of potent antitumor agents |
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| Authors: | T C McMorris M J Kelner W Wang M A Diaz L A Estes R Taetle |
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| Institution: | (1) Department of Chemistry, University of California, San Diego, 92093-0506 La Jolla, California, USA;(2) Department of Pathology University of California, San Diego, 92093-0506 La Jolla, California, USA;(3) Division of Hematology, Arizona Cancer Center, University of Arizona, 1501 N. Campbell Avenue, 95724 Tucson, Arizona, USA |
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| Abstract: | Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.Unfortunately, publication was held up due to postal delay. |
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| Keywords: | Acylfulvene illudin S sesquiterpene antitumor agents |
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