Molecular characterization of avian influenza virus (H7N8) isolated from poultry in Central China in the mid-1980s |
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Authors: | JiaLin Yang Han Xia JiuRu Zhao XiaoBin He LiMin Pan Shuang Tang Zhong Zhang Zheng Kou TianXian Li |
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Affiliation: | State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China *These authors contributed equally to this work. |
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Abstract: | The molecular and pathogenic properties of avian influenza virus (A/duck/Hubei/216/1985/H7N8) isolated from Hubei Province of China in 1985 were characterized.The hemagglutinin gene (HA) of Dk/Hb/216/85/H7N8 had the multiple amino acid se-quences (-PEIPKGRG-) at the connecting peptide between HA1 and HA2, which is considered to be a distinguishing molecular characteristic of low pathogenicity.The key sites of host markers among the genes (M, NP, NS, PA and PB2) of Dk/Hb/ 216/85/H7N8 were similar to those of... |
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Keywords: | avian influenza virus low pathogenicity H7N8 H5N1 |
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