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Molecular characterization of avian influenza virus (H7N8) isolated from poultry in Central China in the mid-1980s
Authors:JiaLin Yang  Han Xia  JiuRu Zhao  XiaoBin He  LiMin Pan  Shuang Tang  Zhong Zhang  Zheng Kou  TianXian Li
Affiliation:State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China 
*These authors contributed equally to this work.
Abstract:The molecular and pathogenic properties of avian influenza virus (A/duck/Hubei/216/1985/H7N8) isolated from Hubei Province of China in 1985 were characterized.The hemagglutinin gene (HA) of Dk/Hb/216/85/H7N8 had the multiple amino acid se-quences (-PEIPKGRG-) at the connecting peptide between HA1 and HA2, which is considered to be a distinguishing molecular characteristic of low pathogenicity.The key sites of host markers among the genes (M, NP, NS, PA and PB2) of Dk/Hb/ 216/85/H7N8 were similar to those of...
Keywords:avian influenza virus  low pathogenicity  H7N8  H5N1  
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