Androgen dependency of hepatic hydroxysteroid dehydrogenases in the rat: Prepubertal responsiveness and unresponsiveness towards exogenous testosterone |
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| Authors: | H-G Hoff R Ghraf E R Lax H Schriefers |
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| Institution: | (1) Institut für Physiologische Chemie und Medizinische Klinik der Universität Essen, Hufelandstrasse 55, D-43 Essen, (Federal Republic of Germany) |
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| Abstract: | Summary The prepubertal responsiveness of 3 typical androgen-dependent enzyme activities, namely 20-ketoreductase, 3 - and  4-3 -hydroxysteroid dehydrogenase, towards a large dose of testosterone was investigated. The androgen induced the activity of the 3-enzyme prepubertally in both sexes.This investigation was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 87, Endokrinologie). |
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