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Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin. |
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| Authors: | G Jones J B Greig |
| Abstract: | In C57BL/6 mice a single oral dose of 2,3,7,8-tetrachlorodibenzodioxin (LD50 126 mug/kg) results in loss of body weight and death with an enlarged fatty liver after ca. 21 days. A progressive necrotic centrilobular liver lesion is also seen. |
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