Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes |
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Authors: | P Kisielow H Blüthmann U D Staerz M Steinmetz H von Boehmer |
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Affiliation: | Basel Institute for Immunology, Switzerland. |
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Abstract: | The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells. |
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