| 纳米羟基磷灰石对两种药物的载药性能研究 |
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| 引用本文： | 陈庆榆,朱融融,张蕤,田川,孙晓宇,汪世龙.纳米羟基磷灰石对两种药物的载药性能研究[J].复旦学报(自然科学版),2009,48(3). |
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| 作者姓名： | 陈庆榆 朱融融 张蕤 田川 孙晓宇 汪世龙 |
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| 作者单位： | 陈庆榆,CHEN Qin-yu(安徽科技学院,蚌埠,233100);朱融融,张蕤,田川,孙晓宇,汪世龙,ZHU Rong-rong,ZHANG Rui,TIAN Chuan,SUN Xiao-yu,WANG Shi-long(同济大学,生命科学与技术学院,上海200092)
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| 基金项目： | 国家自然科学基金，国家高技术研究发展计划(863计划) |
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| 摘 要： | 骨缺损常常伴随着炎症、肿瘤等情况,以各种骨修复材料为载体的药物缓释体系是一种新型的给药方式.以纳米羟基磷灰石(n-HA)为载药体系,用红外光谱和透射电镜表征了n-HA的结构,考察了其对抗生素阿莫西林和抗肿瘤药鬼臼毒素的不同吸附作用,并研究其对抗生素阿莫西林吸附量的影响.实验结果表明,n-HA的红外图谱及粒径与人体骨颇为接近,同时n-HA可以吸附有羟基的阿莫西林,并且吸附性能随着阿莫西林初始浓度的不同而不同,吸附速度快,4 h达到吸附平衡;但是对没有特征基团的鬼臼毒素,n-HA不能吸附.n-HA这种对有某些特征基团分子的特异性吸附作用,对载药骨材料的研究具有非常重要的指导意义.
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| 关 键 词： | 纳米羟基磷灰石 载药 阿莫西林 鬼臼毒素 生物相容性 |
Preparation and Characterization of Nanohydroxyapatite as Carrier of Two Drugs |
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| CHEN Qin-yu,ZHU Rong-rong,ZHANG Rui,TIAN Chuan,SUN Xiao-yu,WANG Shi-long.Preparation and Characterization of Nanohydroxyapatite as Carrier of Two Drugs[J].Journal of Fudan University(Natural Science),2009,48(3). |
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| Authors: | CHEN Qin-yu ZHU Rong-rong ZHANG Rui TIAN Chuan SUN Xiao-yu WANG Shi-long |
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| Institution: | 1.Anhui Science and Technology Institute;Bangbu 233100;China;2.School of Life Science and Technology;Tongji University;Shanghai 200092;China |
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| Abstract: | Bone defect is usually accompanied with inflammation and tumor.Control delivery system based on bone repair material is a new type of drug delivery methods.n-HA is prepared and evaluated as the drug delivery system for amoxicillin and podophyllotoxin.TEM and FTIR were used for the detection of the morphology of n-HA and the absorption ratio of amoxicillin and podophyllotoxin.The results showed that the IR spectrum of n-HA is similar to that of natural bone.It's also revealed that amoxicillin with-OH can be ... |
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| Keywords: | Nano-hydroxyapatite drug carrier amoxicillin podophyllotoxin biocompability |
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