Epitope mimics and determinant spreading: pathways to autoimmunity |
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Authors: | Farris A D Keech C L Gordon T P McCluskey J |
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Institution: | Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. |
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Abstract: | Infectious microorganisms have evolved molecules which mimic the host in order to aid in their undetected propagation. In response, mammalian hosts have evolved a highly diverse immune repertoire designed to eradicate rapidly changing pathogens. The generation of diversity in the immune repertoire results in potentially damaging self cross-reactivities which require multiple regulatory controls to keep autoreactive lymphocytes in check. Here, we review how molecular mimicry at the T cell level might be important in the development of systemic autoimmunity. |
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