| 单加成C60衍生物对HeLa细胞生长的影响 |
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| 引用本文： | 程福永,杨新林.单加成C60衍生物对HeLa细胞生长的影响[J].北京理工大学学报,2000,20(2):261-264. |
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| 作者姓名： | 程福永 杨新林 |
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| 作者单位： | 北京理工大学,材料科学研究中心,北京,100081 |
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| 基金项目： | 国家自然科学基金;59702009; |
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| 摘 要： | 研究单加成Ｃ６衍生物对人宫颈癌ＨｅＬａ细胞生长的影响,合成了Ｃ６０羧酸酯（Ｃ１）和Ｃ６０甘氨酸酯（Ｃ２）两个单加成的Ｃ６０衍生物;制备了Ｃ６０及两个衍生物的聚乙烯基吡咯烷酮水溶液,并利用ＭＴＴ法研究了它们以人宫颈癌ＨｅＬａ细胞的作用。Ｃ６０,Ｃ１在不光照及两种光照条件下对ＨｅＬａ细胞的生长均不起作用,而Ｃ２在功率为３００Ｗ的碘钨灯光照时则表现出明显的抑制作用。该结果提示Ｃ６０衍生物对细胞生长的作用
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| 关 键 词： | HeLa细胞 光敏效应 单加成碳60衍生物 生长 |
Influence of C60 Monoadducts on the Growth of Hela Cells |
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| CHENG Fu-yong,YANG Xin-lin,ZHU He-sun.Influence of C60 Monoadducts on the Growth of Hela Cells[J].Journal of Beijing Institute of Technology(Natural Science Edition),2000,20(2):261-264. |
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| Authors: | CHENG Fu-yong YANG Xin-lin ZHU He-sun |
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| Abstract: | To study the influence of C6o monoadducts on the growth of Hela cells, two C6o monoadducts: ethyl caboxylic C6o, (C1) and glycinate derivative of C6o, (C2) were prepared; C6o,C1 and C2 were introduced into water with PVP and then their effects on the growth of HeLa cells were studied by MTT assay under different irradiation conditions. Both PVP solutions of C6o and C1 showed no obvious effect on the growth of HeLa cells under any of three irradiation conditions (the power of the light was o W, 1oo W, 3oo W,respectively), while C2 can remarkably inhibit HeLa cells growth when the light power is 3oo W. The effects of C6o derivatives on the cells growth were related to the side chain structure, and were also dependent on the power of the light irradiation. |
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| Keywords: | C_(60) C_(60) monoadducts HeLa cells photosensitization |
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