| 降钙素基因相关肽和内皮素-1对支气管上皮细胞与嗜酸性粒细胞黏附功能的影响 |
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| 引用本文： | 张坚松,王笑梅,李翔,邢秀梅,麻小浩.降钙素基因相关肽和内皮素-1对支气管上皮细胞与嗜酸性粒细胞黏附功能的影响[J].湖南师范大学自然科学学报,2007,30(4):94-98. |
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| 作者姓名： | 张坚松 王笑梅 李翔 邢秀梅 麻小浩 |
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| 作者单位： | 湖南师范大学医学院,中国,长沙,410006 |
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| 基金项目： | 国家自然科学基金资助项目(30270586)，湖南省自然科学研究基金资助项目(04JJ3015)，湖南省卫生厅科研基金资助项目(B2005112) |
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| 摘 要： | 观察肺内调节肽对嗜酸性粒细胞(EOS)与支气管上皮细胞(BEC)粘附功能的影响.选择降钙素基因相关肽(CGRP)和内皮素-1(ET-1)两种调节肽作为研究对象,观察它们对BEC白细胞介素(ILs)分泌及细胞间粘附分子-1(ICAM-1)表达的影响.结果表明:CGRP,ET-1可使O3应激的BEC分泌ILs能力升高,并上调气道上皮ICAM-1的表达.CGRP、ET-1能促进BEC与EOS的粘附,对气道炎症起正性调节作用,加重局部的损伤.
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| 关 键 词： | 肺内调节肽 降钙素基因相关肽 内皮素-1 支气管上皮细胞 嗜酸性粒细胞 |
| 文章编号： | 1000-2537（2007）04-0094-05 |
| 收稿时间： | 2007-05-06 |
| 修稿时间： | 2007年5月6日 |
Effect of Calcitonin Gene-related Peptide and Endothelin-Ⅰ on the Adhesion of Eosinophil to Bronchial Epithelial Cells |
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| ZHANG Jiang-song , WANG Xiao-mei, LI Xiang ,XIN Xiu-mei.Effect of Calcitonin Gene-related Peptide and Endothelin-Ⅰ on the Adhesion of Eosinophil to Bronchial Epithelial Cells[J].Journal of Natural Science of Hunan Normal University,2007,30(4):94-98. |
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| Authors: | ZHANG Jiang-song WANG Xiao-mei LI Xiang XIN Xiu-mei |
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| Institution: | Medical College, Hunan Normal University, Changsha 410006, China |
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| Abstract: | To investigate the effect of intrapulmonary regulatory peptides on adhesion of eosinophils(EOS) to bronchial epithelial cells(BECs).Two regulatory peptides,namely calcitonin gene-related peptide(CGRP) and endothelin-1(ET-1) were investigated.CGRP and ET-1 were observed on the secretion of ILs and expression of intercellular adhesion molecule-1(ICAM-1).The results show CGRP and ET-1 could increase ILs secretion and ICAM-1 expression.CGRP and ET-1 accelerated the adhsion of EOS to BEC in the inflammatory process to aggravated the airway inflammation. |
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| Keywords: | regulatory peptides calcitonin gene-related peptide endothelin-1 bronchial epithelial cells eosinophil |
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