| 硒对慢性氟中毒致雄性大鼠生殖毒性的拮抗作用 |
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| 引用本文： | 尉俊仁,冯佩,章子贵.硒对慢性氟中毒致雄性大鼠生殖毒性的拮抗作用[J].浙江师范大学学报(自然科学版),2011,34(1):86-90. |
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| 作者姓名： | 尉俊仁 冯佩 章子贵 |
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| 作者单位： | 浙江师范大学,化学与生命科学学院,浙江,金华,321004 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 为了探讨硒对氟致睾丸损伤的拮抗作用,以雄性SD大鼠为实验动物,在饮水中加氟化钠(50 mg/L)、亚硒酸钠(分别为0.375,0.750和1.500 mg/L),单纯喂养或硒氟两两组合喂养6个月,断头处死,用试剂盒测大鼠睾丸组织中乳酸脱氢酶(LDH)、酸性磷酸酶(ACP)、碱性磷酸酶(AKP)及三磷酸腺苷酶(ATPase)的活性.结果发现:1)大鼠体质量:氟加低硒组、氟加中硒组高于对照组,差异有统计学意义(P<0.05).2)LDH活性:染氟组低于对照组,中硒组、高硒组、氟加高硒组高于染氟组(P<0.05);AKP活性:染氟组低于对照组,而氟加中硒组高于对照组(P<0.05);ACP活性:染氟组高于对照组(P<0.05).3)Na+,K+-ATPase活性:高硒组及氟加高硒组较对照组降低;Ca2+-ATPase活性:中硒组和氟加高硒组高于对照组,差异均有统计学意义(P<0.05).研究表明硒可以对慢性氟中毒导致的雄性生殖毒性产生拮抗作用,不同酶对拮抗作用的敏感性不同.
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| 关 键 词： | 氟 硒 雄性生殖毒性 拮抗作用 |
Effect of combined exposure to fluoride and selenium on biochemical functions of the testis of male rats |
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| WEI Junren,FENG Pei,ZHANG Zigui.Effect of combined exposure to fluoride and selenium on biochemical functions of the testis of male rats[J].Journal of Zhejiang Normal University Natural Sciences,2011,34(1):86-90. |
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| Authors: | WEI Junren FENG Pei ZHANG Zigui |
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| Institution: | WEI Junren,FENG Pei,ZHANG Zigui(College of Chemistry and Life Science,Zhejiang Normal University,Jinhua Zhejiang 321004,China) |
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| Abstract: | It was aimed to study the antagonism of selenium on male reproductive toxicity induced by excessive fluorine,the male SD rats deionized water supplemented with NaF or/and Na2SeO3 were fed for six months.The body weights,testical,epididymitis and its organic coefficient were measured and calculated;the levels of lactate dehydrogenase(LDH),acid phosphatase(ACP),alkaline phosphatase(AKP),Na+K+-ATPase,Mg2+-ATPase,Ca2+-ATPase were examined.The results showed that: 1) Weigh of rats was significantly increased(P<0... |
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| Keywords: | selenium fluoride male reproductive toxicity antagonism |
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