Modulation of neuronal activity of cerebellar fastigial nucleus by locus coeruleus stimulation in the rat |
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Authors: | Wang Tao Wang Jianjun Cheng Hong Li Hongzhao Yu Qixiang |
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Institution: | (1) Department of Biological Science and Technology, Nanjing University, 210093 Nanjing, China;(2) Present address: The People’s Haqpital of Jiangsu Province, 210029 Nanjing, China |
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Abstract: | The effects of stimulating locus coeruleus (LC) on neuronal activity of cerebellar fastigii nucleus (FN) was investigated.
Stimulation of LC elicited inhibitory, excitatory and biphasic (inhibition-excitation) responses from FN cells. The majority
of responsive cells showed an inhibitory response with a latency of less than 10 ms. Injection of a adrenoreceptor antagonists
phentolamine (iV) could block the inhibitory response of FN cells to the LC stimulation, but propranolol (IV), a β adrenoreceptor
antagonist, could not. These results suggest that LC-cerebellar noradrenergic afferent fibers may be involved in the cerebellar
sensorimotor integration process by exerting their modulatory action on the cerebellar nuclear cells’ activities. |
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Keywords: | locus coeruleus cerebellar fastigial nucleus coearuleo-cerebellar pathway noradrenergic fibers |
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